机构地区:[1]首都医科大学附属北京安贞医院急诊危重症中心,100029 [2]保定市第一中心医院心内科,河北保定071000 [3]首都医科大学,北京100069
出 处:《中华危重病急救医学》2016年第12期1080-1085,共6页Chinese Critical Care Medicine
基 金:国家高技术研究发展计划项目(2015AA020102);国家自然科学基金面上项目(81270284);北京市自然科学基金重点项目(7141003)
摘 要:目的分析急性心肌梗死(AMI)并发不同部位心脏破裂患者的临床特征及预后。方法回顾性分析2010年1月至2015年12月首都医科大学附属北京安贞医院收治的确诊为AMI并发生心脏破裂住院患者的临床资料,电话或门诊随访患者出院30d的预后情况。根据心脏破裂部位将患者分为游离壁破裂组和室间隔穿孔组,比较患者一般临床资料、住院相关检查结果、治疗及预后等情况。结果共纳入120例AMI并发心脏破裂患者,其中游离壁破裂64例,室间隔穿孔56例。与室间隔穿孔组比较,游离壁破裂组患者年龄大(岁:68.88±9.31比63.86±8.68,t=3.039,P=0.003),体重指数(BMI)低(kg/m^2:22.74±2.07比25.21±2.99,t=-5.203,P=0.000),肾功能不全病史比例高(12.5%比1.8%,X^2=4.942,P=0.026),天冬氨酸转氨酶[AST(U/L):76.00(38.33,197.50)比33.50(19.00,137.50),Z=-2.788,P=O.005j、甘油三酯[TG(mmol/L):1.68±0.50比1.36±0.70,t=2.903,P=0.005]、总胆固醇[TC(mmol/L):4.21±0.74比3.87±1.01,t=2.081,P=0.040]、高密度脂蛋白胆固醇[HDL-C(mmol/L):1.12±0.91比0.91±0.32,t=2.910,P=O.004]和心肌肌钙蛋白I[eTnI(μg/L):18.83(4.48,81.68)比0.82(0.08,8.50),Z=-5.011,P=0.000]明显升高;尿素氮[BUN(mmol/L):7.11±3.11比10.14±6.97,t=-2.999,P=0.004]、脑钠肽[BNP(ng/L):169.00(98.50,485.75)比793.00(478.75,1426.25),Z=-5.739,P=0.000]及D-二聚体[μg/L:219.00(141.00,315.75)比310.50(188.75,532.00),Z=-2.607,P=0.009]显著降低;左心室舒张期末内径[LVEDD(mm):48.58±5.17比53.65±6.63,t=-4.631,P=0.000]和左心室收缩期末内径[LVESD(mm):33.54±5.40比37.24±6.53,t=-3.397,P=0.001]明显缩小;室Objective To analyze the clinical features and prognosis of patients with acute myocardial infarction (AMI) complicated with different parts of heart rupture. Methods Patients diagnosed for AMI complicated with cardiac rupture from January 2010 to December 2015 in Beijing Anzhen Hospital were collected. All of them were divided into free wall rupture group and ventricular septal perforation group according to the rupture site. Clinical features, hospital related examination results, treatment and prognosis of these two groups were analyzed statistically. Results A total of 120 patients with AMI complicated with cardiac rupture were included in the study, including 64 patients with free wall rupture, and 56 patients with ventricular septal perforation. Compared with the ventricular septalperforation group by the single factor analysis, the patients in free wall rupture group had higher age (year: 68.88±9.31 vs. 63.86 ± 8.68, t = 3.039, P = 0.003), lower body mass index [BMI (kg/m2^): 22.74 ± 2.07 vs. 25.21 ± 2.99, t = -5.203, P = 0.000], higher rate of history of renal insufficiency (12.5% vs. 1.8%, X^2 = 4.942, P = 0.026), higher level of aspartate transaminase [AST (U/L): 76.00 (38.33, 197.50) vs. 33.50 (19.00, 137.50), Z = -2.788, P = 0.005], triglyeeride [TG (mmol/L): 1.68±0.50 vs. 1.36±0.70, t = 2.903, P = 0.005], total cholesterol [TC (mmol/L): 4.21±0.74 vs. 3.87± 1.01, t = 2.081, P = 0.040], high density lipoprotein cholesterol [HDL-C (mmol/L): 1.12 ± 0.91 vs. 0.91 ± 0.32, t = 2.910, P = 0.004] and cardiac troponin I [eTnI (μg/L): 18.83 (4.48, 81.68) vs. 0.82 (0.08, 8.50), Z =-5.011, P = 0.000], lower level of blood urea nitrogen [BUN (mmol/L): 7.11 ± 3.11 vs. 10.14 ± 6.97, t = -2.999, P = 0.004], brain natriuretie peptide [BNP (ng/L): 169.00 (98.50, 485.75) vs. 793.00 (478.75, 1 426.25), Z = -5.739, P = 0.000], and D-dimer [μg/L: 219.00 (141.00, 315.75) vs. 310.50 (188.75, 532.00), Z = -2.607, P =
关 键 词:心肌梗死 急性 心脏破裂 游离壁破裂 室间隔穿孔 预后
分 类 号:R542.22[医药卫生—心血管疾病]
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