长链非编码RNA(lncRNA)及其在昆虫学研究中的进展  

Long noncoding RNAs( lncRNAs) and their research advances in entomology

作　　者：朱斌[1] 梁沛[1] 高希武[1] ZHU Bin LIANG Pei GAO Xi-Wu(Department of Entomology, China Agricultural University, Beijing 100193, China)

机构地区：[1]中国农业大学昆虫学系,北京100193

出　　处：《昆虫学报》2016年第11期1272-1281,共10页Acta Entomologica Sinica

基　　金：国家自然科学基金项目(31572023);公益性行业(农业)科研专项(201203038)

摘　　要：长链非编码RNA(long noncoding RNA,lncRNA)是一类转录本长度超过200 nt的非编码RNA,主要通过转录调控和转录后调控调节基因的表达,也可通过影响蛋白质定位和端粒复制发挥其强大的生物学功能。本文在介绍lncRNA的特征、分类及其主要作用机制的基础上,综述了有关昆虫lncRNA的鉴定及功能研究等方面的最新进展。近5年来已经从黑腹果蝇Drosophila melanogaster、小菜蛾Plutella xylostella和褐飞虱Nilaparvata lugens等8种昆虫中鉴定出了大量lncRNA,为进一步研究lncRNA在昆虫生长发育过程中的功能奠定了重要基础。非编码RNA参与调控害虫抗药性的分子机制已经成为昆虫毒理学研究的一个新兴领域,因此本文对有关lncRNA与害虫抗药性关系的最新研究进展也做了介绍。【Aim】Long noncoding RNAs（ lncRNAs） are a novel class of non-protein coding transcripts longer than 200 nt and regarded as a kind of key regulatory molecules which could regulate gene expression at many different levels including transcriptional and post-transcriptional levels. In this article,the characteristics,classification and mode of actions of lncRNAs were summarized,and the recent advances of lncRNA research in entomology were reviewed. In the last five years,a huge amount of lncRNAs have been identified from eight insects including Drosophila melanogaster,Plutella xylostella and Nilaparvata lugens,providing important foundation for further exploration of lncRNA function in insect development. At the same time,lncRNA mediated insecticide resistance has become an emerging field of insecticide toxicology,so the very recent advances in lncRNAs involved in insecticide resistance were also reviewed.

关 键 词：长链非编码RNA 昆虫 分类 生物学功能 抗药性 

分 类 号：Q965.9[生物学—昆虫学]