转录因子SCX和MKX在肌腱发育和分化中的研究进展  

Transcription Factors SCX and MKX Research Progress in Tendon Development and Differentiation

作　　者：吴震[1] 张子旺 王晓艾[3] 郑莉灵 吴芳[3] Wu Zhen Zhang Ziwang Wang Xiaoai Zheng Liling Wu Fang(Tongde Hospital of Zhejiang Province, Hangzhou 310012, China Zhejiang University School of Medicine, Hangzhou 310058, China The Children ＇s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China)

机构地区：[1]浙江省立同德医院,杭州310012 [2]浙江大学医学院,杭州310058 [3]浙江大学医学院附属儿童医院,杭州310003

出　　处：《中国细胞生物学学报》2016年第12期1549-1554,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31201017);浙江省科技创新团队(批准号:2013TD11)资助的课题~~

摘　　要：肌腱损伤是临床的常见病之一,其愈合后易发生黏连而影响肌腱功能,因此,有效地改善和促进愈合、恢复肌腱功能成为亟待解决的主要问题。为求在根源上找到解决问题的方法,众多学者对肌腱发育的机制进行了大量的研究,发现了肌腱发育和分化的关键转录因子Scleraxis(SCX)和Mohawk(MKX)。为了更好地了解肌腱发育机制,该文主要对转录因子SCX和MKX的发现、在肌腱中的分布和功能以及参与的信号通路等方面进行了阐述。Tendon injury is one of common clinical diseases. It is very easily to do harm to tendon function due to the adhesion. Thus, the effective improvement and promotion of healing and recovering of tendon function become main problems to be solved. In order to find the methods to solve the problem at the source, many scholars on tendon development mechanism carried out a large amount of research, finding that the key transcription factors of tendon development and differentiation are SCX （Scleraxis） and MKX （Mohawk）. In order to have a better understanding about the tendon development mechanism, this paper mainly introduce the discovery of transcription factor SCX and MKX along with their function, signaling pathways and some other aspects involved in the tendon.

关 键 词：转录因子 SCX MKX FGFs信号通路 TGFβ信号通路 

分 类 号：R346[医药卫生—基础医学]