原发性高血压并发心肌梗死患者AT1-AA表达及AT1-AA对大鼠冠脉血管的影响初探  

AT1-AA expression of patients with essential hypertension complicated with myocardial infarction and effect of AT1-AA on the coronary artery in rats

作　　者：张媛[1] 钟晓鸣[1] 李彦明[1] Zhang Yuan Zhong Xiaoming Li Yanming(Department of Cardiovascular Medicine ,Huaihe River Hospital of Henan Universit)

机构地区：[1]河南大学淮河医院心血管内科,开封475000

出　　处：《重庆医科大学学报》2016年第12期1222-1225,共4页Journal of Chongqing Medical University

摘　　要：目的:探讨原发性高血压并发心肌梗死患者抗血管紧张素Ⅱ1型受体自身抗体(angiotensinⅡtype 1 receptor-activating antibody,AT1-AA)改变与AT1-AA对鼠冠脉血管的影响。方法:选取2014年6月至2015年7月我院收治的原发性高血压并发心肌梗死患者47例(高血压+心肌梗死组)、高血压患者96例(高血压组)、心肌梗死患者53例(心肌梗死组),随机选取同期到我院接受体检的健康者65例组成健康对照组,比较4组受试者的AT1-AA滴度、水平、阳性率及不同浓度AT1-AA下鼠冠脉血管指标。结果:高血压+心肌梗死组患者的AT1-AA滴度、水平及阳性率均明显高于高血压组和心肌梗死组,3组患者的AT1-AA滴度、水平及阳性率明显高于健康对照组,差异具有统计学意义(P<0.05)。0、10-8、10-7、10-6 mol/L浓度下,鼠冠脉血管环静息张力分别为(0.15±0.09)m N、(0.27±0.15)m N、(0.69±0.18)m N、(1.14±0.23)m N,冠脉粥样硬化斑块面积分别为(2.45±0.47)%、(11.78±2.78)%、(19.16±2.52)%、(26.79±4.91)%,组间差异具有统计学意义(P<0.05),并随AT1-AA浓度变化而变化,趋势显著(P<0.05)。鼠冠脉血管环静息张力(r=0.792,P=0.026)、冠脉粥样硬化斑块面积(r=0.720,P=0.031)与AT1-AA均呈明显正相关关系。结论:原发性高血压并发心肌梗死患者的AT1-AA水平明显升高,AT1-AA可导致鼠冠脉血管收缩能力增加及粥样硬化斑块面积扩大。Objective：To investigate the changes of angiotensinⅡtype 1 receptor-activating antibody（AT1-AA）in patients with essential hypertension complicated with myocardial infarction and to explore the effect of AT1-A on rat coronary blood vessels. Methods：A total of 47 patients with essential hypertension complicated with myocardial infarction from June 2014 to July 2015 in our hospital were enrolled（hypertension and myocardial infarction group）;96 patients with high blood pressure were taken as hypertension group,53 patients with myocardial infarction as myocardial infarction group and 65 healthy controls as healthy control group. AT1-AA titer level,positive rate and coronary vascular index under different concentrations of AT1-AA of four groups were compared. Results：AT1-AA titer level and positive rate were higher in hypertension and myocardial infarction group than in hypertension group and myocardial infarction group;AT1-AA titer level and positive rate were lower in healthy control group than in the other three groups,with statistically significant difference（P〈0.05）. Under 0,10^-8,10^-7,10^-6 mol/L concentration,rat coronary vascular rings resting tension was（0.15±0.09）m N,（0.27±0.15）m N,（0.69±0.18）m N,（1.14±0.23）m N;coronary atherosclerotic plaque area was（2.45±0.47）%,（11.78±2.78）%,（19.16±2.52）%,（26.79±4.91）%,with statistics significances（P〈0.05）. And with the change of AT1-AA concentration,the trend was more significant（P〈0.05）. Rat coronary vascular rings resting tension（r=0.792,P=0.026）,coronary atherosclerotic plaque area（r=0.720,P=0.031）and AT1-AA were positively correlated. Conclusion：AT1-AA levels significantly are increased in patients with essential hypertension complicated with myocardial infarction. AT1-AA can lead to enhanced coronary vasoconstriction and expand the area of atherosclerotic plaque.

关 键 词：原发性高血压 心肌梗死 抗血管紧张素Ⅱ1型受体自身抗体 鼠冠脉血管 

分 类 号：R543.3[医药卫生—心血管疾病]