2006-2015年陕西省百日咳发病特征及人群抗体水平监测研究  

Epidemiological characteristic of pertussis and sero-epidemiology investigation of the population in Shanxi Province,2006-2015

作　　者：胡伟军[1] 张少白[1] 

机构地区：[1]陕西省疾病预防控制中心,陕西西安710054

出　　处：《现代预防医学》2017年第1期163-166,共4页Modern Preventive Medicine

摘　　要：目的分析陕西省2006-2015年百日咳流行特征及人群抗体水平,为防控策略制定提供参考依据。方法通过描述性方法分析我省近10年百日咳发病特征变化,用酶联免疫吸附实验检测人群血清百日咳抗体水平。结果陕西省2006-2015年百日咳发病整体呈上升趋势,2015年发病率达到1.96/10万,近10年百日咳发病人群主要为0岁组人群,占比67.60%,2014、2015两年关中地区发病率升高明显,百日咳发病时间分布仍主要集中在5~9月份,但由原来的双峰分布变为近年的单峰分布。960份健康人群血清标本Ig G抗体几何平均浓度22.47 IU/ml,阳性701例,阳性率73.02%,3~5岁和6~9岁组抗体几何平均浓度低于其他年龄组,差异具有统计学意义(F=22.73,P<0.001)人群抗体水平整体呈高转低再升高的趋势。结论陕西省近年来百日咳发病有升高趋势,同时发病特征有所改变,人群抗体监测发现3~9岁组抗体水平低下,下一步应加强疾病监测敏感性并针对重点地区和易感人群采取必要防控措施。Objective To analyze the epidemiological characteristic of pertussis in Shanxi province from 2006 to 2015 and antibody level of the population, and to understand the influencing factors of high incidence of pertussis and to provide a reference for prevention and control strategy. Methods The data of pertussis in recent 10 years in our province was analyzed by the descriptive study. The level of antibody against pertussis was tested by ELISA methods. Results Pertussis morbidity showed an upward trend from 2006 to 2015 in Shanxi province, especially in 2015,when incidence rate reached 1.96/10 million. The pertussis cases in the last 10 years were mainly in the age group of 0 years （67.60%） ,and significantly increased in the middle of Shanxi province between 2014 and 2015. The distribution of pertussis onset time was mainly concentrated from May to September,but from the original double -peak distribution into single -peak distribution in recent years. We tested 960 serological samples,found that there were 701 positive eases and the antibody positive rate to pertussis was 73.02% with the geometric mean （GMC） of 22.47 IU/ml. The GMC of 3 - 5 and 6 - 9 age old group were lower than the other groups （ F = 22. 73 ,P 〈 0. 001 ）. The trend was declined from high level then turn back. Conclusion The morbidity of pertussis shows upward tendency and the epidemiological characteristic of pertussis in Shanxi has changed. The antibody of pertussis is low in 3 - 9 age group. The research prompts us that we should increase the level of pertussis surveillance and take necessary prevention and control measures for the key area and susceptible population.

关 键 词：百日咳 发病特征 抗体监测 影响因素 

分 类 号：R195.4[医药卫生—卫生统计学]