电感耦合等离子体原子发射光谱法测定艾司奥美拉唑镁中镁的含量  

Content Determination of Magnesium in Esomeprazole Magnesium by Inductive Coupled Plasma Atomic Emission Spectrometry

作　　者：姜鹰雁 耿志鹏 刘燕 杨琪 杨海霞 

机构地区：[1]山东省药学科学院山东省生物药物重点实验室,济南250101

出　　处：《中国药师》2017年第1期154-156,共3页China Pharmacist

基　　金：国家"重大新药创制"科技重大专项(编号:2009ZX09301-013)

摘　　要：目的:建立艾司奥美拉唑镁中镁含量的测定方法。方法:采用电感耦合等离子体原子发射光谱法测定艾司奥美拉唑镁中的镁含量。结果:镁在10.0~80.0μg·ml^(-1)浓度范围内线性关系良好(r=0.999 8),平均回收率为99.55%(RSD=1.35%,n=9),检出限为0.000 75μg·ml^(-1),定量限为0.002 5μg·ml^(-1)。结论:该法准确、灵敏、重复性好,可用于艾司奥美拉唑镁中镁含量的测定。Objective： To establish a method for the content determination of magnesium in esomeprazole magnesium. Methods： The content of magnesium in esomeprazole magnesium was determined by inductive coupled plasma atomic emission spectrometry. Re- sults： The linear range was 10.0-80.0 μg·ml-1 （ r = 0.999 8 ）. The average recovery was 99.55% with RSD of 1.35% （ n = 9 ）. The detection limit was 0. 000 75 μg·ml-1 and the quantitative limit was 0.002 5 μg·ml-1. Conclusion： The method is accurate, sensitive and reproducible, which can be used for the content determination of magnesium in esomeprazole magnesium.

关 键 词：艾司奥美拉唑镁 镁 含量测定 电感耦合等离子体原子发射光谱法 

分 类 号：R917[医药卫生—药物分析学]