细胞膜修饰的纳米粒载药系统的研究进展  

Advances of Cell Membrane-camouflaged Nanoparticles Delivery System

作　　者：顾晓彤[1] 李杨[1] 王栋 王永禄[1] 李学明[1,2] 

机构地区：[1]南京工业大学药学院,江苏南京211816 [2]南京百思福医药科技有限公司,江苏南京210032

出　　处：《中国医药工业杂志》2017年第1期94-101,共8页Chinese Journal of Pharmaceuticals

摘　　要：近年来,以纳米粒为载体的递药系统研究取得了较大进展,然而纳米粒在体内会产生免疫原性和纳米毒性。因此,细胞膜作为一种更安全有效的载体已成为药物传递领域的研究热点。将细胞膜与纳米粒进行结合,不仅能增加纳米粒的生物相容性,还可以通过选择不同种类细胞膜,如血细胞、干细胞或细菌细胞等,使纳米粒获得靶向性、不易被免疫系统识别且能延长体循环时间等多种生物学特性。本文介绍了具有生物伪装功能的细胞膜修饰纳米粒的制备方法、特性和应用,以期促进纳米粒在药物传递领域的应用。In recent years, there have been great advances in the development of drug delivery system based on nanoparticles, while they are found to be immunogenic and nanotoxic. Therefore, as a safer and more efficient vector, cell membrane has become a hot research area. Incorporating cell membranes onto nanoparticles enables the nanoparticles having better biocompatibility. Moreover, through modifying with different types of cell membranes, such as blood cells, stem cells and bacteria cells, the nanoparticles will get valuable characters, such as better targeting, lower chance to be recognized by immune system and longer systemic circulation time. In this review, the fabrication processes, characters and applications of cell membrane-camouflaged nanoparticles are introduced to promote the application of nanoparticles to drug delivery system.

关 键 词：细胞膜修饰 纳米粒 生物伪装 药物传递系统 长循环 主动靶向性 综述 

分 类 号：R944[医药卫生—药剂学]