鼠神经生长因子治疗四肢创伤性骨不连27例临床疗效观察  

The Observation of the Rat Nerve Growth Factor in the Treatment of Traumatic Limbs Nonunion

作　　者：刘平胜 黄潮桐 陈隆福 刘宇涛 刘淦良 

机构地区：[1]广东医科大学研究生学院,广东湛江524000 [2]广东省东莞宏元堂中医院 [3]广东医科大学附属厚街医院

出　　处：《中国医学创新》2016年第34期115-118,共4页Medical Innovation of China

摘　　要：目的：探讨鼠神经生长因子（NGF）在治疗四肢创伤性折骨不连的临床治疗效果。方法：对2003年3月-2014年3月期间本院收治的27例四肢创伤性骨折骨不连病例临床资料进行回顾性分析,X线片提示未见明显骨痂生长,于骨折断端周围及骨折间隙内注射鼠神经生长因子（NGF）,1次/周,连续8周,每2周1次定期X线片检查观察骨不连愈合状态。结果：27例病例术后随访10个月-10年,其中26例骨折愈合,1例未见明显骨痂生长,本组有效率96.3%。结论：局部注射鼠神经生长因子治疗骨不连取得较好的治疗效果,具有安全有效、创伤小、并发症少等优点,为骨不连患者提供一种微创无痛的保守治疗方法,但更深入的研究仍缺乏。Objective： To explore the effect of nerve growth factor （ NGF ） in treatment of limbs fracture nonunion and promotion effect of healing.Method： The clinic data of 27 cases with nonunion of limbs fractures from March 2003 to March 2014 were analyzed retrospectively.The X-ray showed no obvious callus growth, they were given injection of mouse nerve growth factor （ NGF ） in the gap of limbs fracture broken end once a week, for 8 weeks, and regular X-ray observation of bone nonunion status once 2 weeks.Result： 27 cases were followed up for 10 months to 10 years.The healing of fracture were 26 cases, 1 case had no obvious callus growth, the effective rate was 96.3%.Conclusion： Local injection of rat nerve growth factor for the treatment of nonunion has better treatment effect with safe and effective, little trauma, fewer complications and it is a particularly noninvasive and painless method of conservative treatment for nonunion patients, but further research is still lacking.

关 键 词：鼠神经生长因子 四肢骨骨折 骨不连 创伤性 治疗 

分 类 号：R683[医药卫生—骨科学]