hs—CRP与pro—BNP联合检测在冠心病诊断中的临床应用  

Combined detection of hs-CRP and N-proBNP levels in the diagnosis of coronary heart disease

作　　者：裴兵 戚小艳 王丹 孙建 王飞 

机构地区：[1]江苏省宿迁市第一人民医院检验学部,223800

出　　处：《检验医学与临床》2016年第A02期91-93,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨血清中超敏C-反应蛋白（hs—CRP）和脑利钠肽前体（N—proBNP）联合检测在诊断冠心病中的价值。方法利用化学发光免疫分析法检测105例冠心痛患者和100例健康人血清中hs—CRP与N—proBNP水平，并对结果进行统计分析。结果冠心病组血清中hs—CRP和N—proBNP含量高于健康对照组，差异有统计学意义（P〈0．05）。单项检测时hs—CRP与N-proBNP的灵敏度度分别为77．6％、71．5％，特异性分别为86．8％、92．5％；联合检测时灵敏度为89．3％，特异性为95．7％。结论hs—CRP与N—proBNP联合检测灵敏度和特异性均高于单项检测，联合检测可有效提高其冠心痛的诊断率。Objective To explore the clinical diagnostic value of combined detection of coronary heart disease. Methods chemi- luminescence immunosssay was used to detect the level of serum hs-CRP and N-proBNP in 105 patients with coronary heart disease and 100 healthy individuals. Results The level of serum hs-CRP and N-proBNP in patients with coronary heart disease were significant higher than that in healthy control group（P〈0.05）, In singlegroup of hs-CRP and N-proBNP, the sensitivities of hs-CRP and N-proBNP were 77.6 % ,71.5%. and the specificites of hs-CRP and N-proBNP were 86.80%, 92.5 %. , respectively the sensitivity and specificity of combined detection of hs-CRP and N-proBNP were 89.3% and 95.7%. Conclusion The sensitivity and specificity of combined detection of hs-CRP and N-proBNP are higher than those of the single detection,and the combined detection can im- prove the detection rate of coronary heart disease,Joint detection can improve the diagnosis rate of coronary heart disease.

关 键 词：超敏C-反应蛋白 脑利钠肽前体 冠心病 联合检测 

分 类 号：R541.4[医药卫生—心血管疾病]