HBsAg阳性妊娠妇女其婴儿的HBV血清标志物模式及意义  

The HBV serum marker＇mode and its significance of newborn infants whose mother are HBsAg positive

作　　者：李攀[1] 王雅宁[1] 

机构地区：[1]河北省保定市第一中心医院东院检验科,071000

出　　处：《检验医学与临床》2016年第A02期117-119,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨妊娠妇女乙型肝炎病毒（HBV）携带状况与胎儿HBV血清标志物模式及其临床意义}探讨抗病毒药物对乙肝母婴传播的阻断效果。方法检测100例HBsAg阳性妊娠妇女血清及其所生婴儿血清的乙肝标志物及乙肝病毒核酸定量（HBV—DNA），将其结果进行分析。结果胎儿血清的乙型肝炎血清标志物的表现模式有11种。新生儿HBV—DNA含量高，传染性强与母血中HBeAg的含量有关。在HBsAg阳性母亲中，血清HBV—DNA阳性的母亲所生婴儿被感染的危险度高于血清HBV—DNA阴性的母亲所生婴儿，两组比较有极显著性意义（X2=16．6P〈0．005）。妊娠妇女自28周起开始服用拉米夫定／替比夫定组和未服用组比较无显著性差异（P〉0．1）。结论HBsAg阳性的妊娠妇女所生婴儿血清的乙肝血清标志物模式具有多样性。妊娠妇女HBeAg和HBV—DNA阳性是胎儿HBV感染的高危因素。怀孕后28周服用抗病毒药物的效果还有待进一步研究。Objective To discuss the correl^ition of the carry status of pregnant women having hepatitis virus B and their babiesr HBV serum marker mode and its clinical significance. To explore the effect of antiviral drugs for interdiction of maternal-neonatal transmission about HBV. Methods To detect the HBV serum marker and HBV-DNA of 100 cases pregnant women who have HB- sag in their serum and their newborn infants,then analyzing the results. Results There are 11 kinds of hepatitis B serum marker models in Fetal serum. The more HBeAg content in Mothersr blood,the more HBV-DNA in their bobies＇ serum,and the highly infectious. For HBsAg positive of the pregnant women, the newborn infants whose mothers are HBV, DNA positive have higher infec- ted risk than the babies whose mothers are HBV-DNA negative,two groups of comparisons has extremely significant significance （X^2= 16.6 P〈0. 005）. there is no significant difference between the group that the Pregnant women started taking lamivudine or Telbivudine from 28 weeks and the group that not taking. Conclusion For HBsAg positive of the pregnant women,The model of the newborn infantst hepatitis B serum marker has diversity. HBeAg positive and HBV-DNA positive of Pregnant women is fetal HBV infection risk factors. The effect of the pregnant women take antiviral drugs after 28weeks still needs a further research.

关 键 词：乙型肝炎病毒 母婴传播 血清标志物模式 

分 类 号：R512.62[医药卫生—内科学]