自噬与A型流感病毒感染  

Autophagy and Infection of Influenza A Virus

作　　者：徐利军[1,2] 刘秀梵[1,3,4] 顾敏[1,3,4] 

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]扬州出入境检验检疫局,江苏扬州225009 [3]江苏省人兽共患病学重点实验室,江苏扬州225009 [4]江苏高校动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《动物医学进展》2017年第1期94-99,共6页Progress In Veterinary Medicine

基　　金：国家蛋鸡产业技术体系项目(nycytx-41-G07);江苏省自然科学基金项目(BK20130442);江苏省高校自然科学研究项目(13KJB230004);江苏高校优势学科建设工程资助项目(PAPD)

摘　　要：自噬是广泛存在于真核细胞内的新陈代谢过程,对于维持细胞自稳具有关键作用。在病毒感染过程中,自噬表现出两面性,既可被利用来促进病毒复制,又在宿主抗感染免疫应答中发挥重要作用。论文以严重危害畜禽生产和人类健康的A型流感病毒为例,论述了细胞自噬与病毒感染及在宿主免疫应答过程中的相互关系,旨在进一步深入理解A型流感病毒的致病分子机制,为抗流感病毒感染的相关研究提供参考。Autophagy is a widely existed metabolic process in eukaryotie cells and is critical for keeping celluar homeostasis . During virus infection , autophagy displays duality as that it could be used to promote virus proliferation on one side, and also it could play key roles in host immune response against viral infection on the other side.In this review,we focused on influenza A virus,which is seriously harmful to animal industry and human health,to discuss the relationship between autophagy and virus infection or host immune response,in order to further deeply understand the molecular mechanism of the viral pathogenicity and to provide reference for anti-influenza virus research.

关 键 词：自噬 A型流感病毒 感染 免疫应答 

分 类 号：S852.43[农业科学—基础兽医学] S852.659.5[农业科学—兽医学]