丁苯酞对急性脑梗死患者认知功能和血清学指标的影响及二者相关性分析  

Effects of Butylphthalide on Cognitive Function and Serology Indexes of Patients with Acute Cerebral Infarction and Analysis of Their Relationship

作　　者：宋轶群[1] 刘梅[2] 于广[1] 

机构地区：[1]天津中医药大学第一附属医院北院老年病科,天津300193 [2]天津中医药大学第一附属医院北院急诊科,天津300193

出　　处：《中国药房》2017年第2期243-246,共4页China Pharmacy

摘　　要：目的:探讨丁苯酞对急性脑梗死(ACI)患者认知功能和血清学指标的影响,并分析二者的相关性。方法:将我院2014年7月-2015年5月的88例ACI患者按照随机数字表法分为对照组(n=38)和观察组(n=50)。对照组患者给予阿司匹林肠溶片100mg(首次剂量300 mg),po,qd,以及吸氧、补液等常规治疗;观察组患者在此基础上给予丁苯酞胶囊0.2 g,po,tid。两组患者均治疗1个月。观察两组患者简易精神状态检查量表(MMSE)评分和血清学指标[血清同型半胱氨酸(Hcy)、基质金属蛋白酶9(MMP-9)、6-酮-前列腺素-F1a(6-k-PGF1a)和神经元特异性烯醇化酶(NSE)],分析观察组患者治疗后MMP-9、6-k-PGF1a、NSE与MMSE总评分的相关性,并记录不良反应发生情况。结果:治疗后,观察组患者的MMSE总评分和6-k-PGF1a水平明显高于对照组,MMP-9、NSE水平明显低于对照组,差异均有统计学意义(P<0.05)。观察组患者的MMP-9、NSE与MMSE总评分呈显著负相关,6-k-PGF1a与MMSE总评分呈显著正相关。观察组患者不良反应发生率(16.0%)与对照组(18.4%)比较,差异无统计学意义(P>0.05)。结论:丁苯酞可明显改善ACI患者的认知功能,安全性较好;血清中MMP-9、NSE、6-k-PGF1a的表达可能与患者的认知功能损伤相关。OBJECTIVE： To investigate the effects of butylphthalide on cognitive function and serology indexes of patients with acute cerebral infarction （ACI）, and to analyze their relationship. METHODS： 88 ACI patients from our hospital during Jul. 2014 to May 2015 were divided into control group （n=38） and observation group （n=50） according to random number table. Con- trol group was given Aspirin enteric-coated tablets 100 mg （initial dose of 300 mg）, po, qd, and routine treatment as oxygen inhalation, fluid replacement. Observation group was additionally given Butylphthalide capsules 0.2 g, po, tid. Both groups received treatment for 1 month. MMSE score and serology indexes （Hey, MMP-9, 6-k-PGFla, NSE） of 2 groups were observed, and the relationship of MMP-9, 6-k-PGFla, NSE with MMSE score in observation group were analyzed after treatment. The occurrence of ADR was recorded. RESULTS： After treatment, MMSE score and 6-k-PGFla level of observation group were significantly higher than those of control group; MMP-9 and NSE levels of observation group were significantly lower than those of control group; with statistical significance （P〈0.05）. MMP-9 and NSE showed significantly negative correlation with MMSE score in observation group, and 6-k-PGFla showed significantly positive correlation with MMSE score. There was no statistical significance in the incidence of ADR between observation group （16.0%） and control group （18.4%） （P〉0.05）. CONCLUSIONS： Butylphthalide can significantly improve cognitive function in ACI patients with good safety. The expression of MMP-9, NSE and 6-k-PGFla in serum may be associated with the cognitive function injury.

关 键 词：丁苯酞 急性脑梗死 认知功能 血清学指标 相关性 

分 类 号：R453[医药卫生—治疗学]