3-[2-取代芳基-1,5-苯并二氮杂-4-基]丙酸乙酯衍生物的高效合成  

An Efficicent Catalytic Synthesis of Derivatives of 3-[2-Substituted Aryl-1,5-Benzodiazepin-4-yl]propionate

作　　者：高蕾[1] 王兰芝[1] 

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050024

出　　处：《化学通报》2017年第1期64-68,共5页Chemistry

基　　金：国家自然科学基金项目(21276064);河北省自然科学基金项目(B2016205165)资助

摘　　要：以取代的芳香醛和乙酰丙酸乙酯为原料,通过Knoevenagel缩合、亲核加成、环合、脱水等过程,快速高效地合成了8种未见文献报道的3-[2-取代芳基-1,5-苯并二氮杂-4-基]丙酸乙酯化合物。通过1H NMR、13C NMR、IR、MS和X射线单晶体衍射确定了目标产物的结构,对合成目标化合物的反应条件进行了较详细的研究,并提出了可能的反应机理。Eight novel compounds of 3-[2-Substituted Aryl-1,5-Benzodiazepin-4-yl]propionate were efficiently synthesized by the Knoevenagel reaction,nucleophilic addition reaction and dehydration cyclization reaction,using substituted aromatic aldehyde and ethyl levulinate as starting material. The structures of these compounds were determined by1 H NMR,13 C NMR,IR,MS and X-ray single crystal diffraction. The exhaustive researches on the synthetic reaction of the class of compounds were carried out,and the reaction mechanism has been unequivocally established in this paper.

关 键 词：KNOEVENAGEL缩合 环合 3-[2-取代芳基-1 5-苯并二氮杂-4-基]丙酸乙酯 

分 类 号：O626[理学—有机化学]