噻唑并[3,2-a]嘧啶衍生物的合成及其在水介质中识别Fe^(3+)的性能  

Synthesis of a Thiazolo[3,2-a]pyrimidine Derivative and Its Recognition Performance for Fe^(3+) in Aqueous Medium

作　　者：钟克利[1] 修萍[1] 郭宝峰[1] 王道林[1] 汤立军[1] 

机构地区：[1]渤海大学化学化工学院,锦州121013

出　　处：《化学通报》2017年第1期84-88,共5页Chemistry

基　　金：国家自然科学基金项目(21304009;21476029);辽宁省高等学校优秀人才支持计划项目(LJQ2014125;LR2015001)资助

摘　　要：噻唑[3,2-a]并嘧啶衍生物具有多种生物活性,但其较差的溶解性限制了其应用。本文在7-(3-氨基苯并呋喃-2-基)-噻唑并[3,2-a]嘧啶-5-酮的芳香环上引入三乙二醇单甲醚,成功合成了化合物L,并利用核磁、质谱对其结构进行了表征。在pH 3.4~6.4范围内,化合物L可在HEPES水溶液中荧光"开-关"识别Fe^(3+),其他金属离子对识别作用没有干扰,该荧光探针具有较高的选择性和较低的检测限。Thiazole[3,2-a]pyrimidine derivatives have a variety of biological activities,but their applications are limited because of their poor solubilities. Thiazole[3,2-a]pyrimidine derivative L has been successfully synthesized by nucleophilic substitution of 7-（3-aminobenzofuran-2-yl） thiazolo[3,2-a]pyrimidin-5-one as aromatic ring matrix with triethylene glycol monomethyl ether. The structure of L was characterized by NMR and high resolution mass spectrum. Compound L can be used for highly selective recognition of Fe3 ＋with a fluorescence＂ONOFF＂response in buffered aqueous solution（HEPES 1 × 10-3mol/L,p H = 6. 4）. The fluorescent probe L displays a wide usable p H range from 3. 4 to 6. 4,non-interference from other metal ions and the low limit of detection.

关 键 词：噻唑并[3 2-a]嘧啶 合成 FE3+ 荧光探针 识别 

分 类 号：O626[理学—有机化学] O657.3[理学—化学]