嗜神经寨卡病毒侵染机制研究进展  

RESEARCH PROGRESS OF ZIKA VIRUS

作　　者：赵欣[1,2] 詹曦菁[1] 张晓龙[2] 刘超[1] 杜蓬[3] 祁军[1] ZHAO Xin ZHAN Xi-Jing ZHANG Xiao-Long LIU Chao DU Peng QI Jun(Tianjin International Travel Health Care Center, Tianjin Entry Exit Inspection and Quarantine Bureau, Tianjin 300456, China China Academy of Inspection and Quarantine, Beijing 100175, China Hangzhou Medical College, Hangzhou 310053, China)

机构地区：[1]天津国际旅行卫生保健中心,天津出入境检验检疫局,天津3000456 [2]中国检验检疫科学研究院,北京100176 [3]杭州医学院,杭州310053

出　　处：《寄生虫与医学昆虫学报》2016年第4期242-248,共7页Acta Parasitologica et Medica Entomologica Sinica

基　　金：浙江省公益技术应用研究计划项目（2017C33075）

摘　　要：寨卡病毒主要通过埃及伊蚊Aedesaegypti传播，可引发婴儿小头畸形症（microcephaly），严重影响小儿神经发育，导致患病胎儿神经系统发育迟缓，严重的甚至引发死胎。笔者对寨卡病毒的病原学、发展和扩散历程、适生地分析、胎儿神经发育过程相关受体及信号通路进行整合综述。Zika virus is primarily transmitted to people through the bite of infected Aedes mosquitoes which also distributed Guangdong, Guangxi, Yunnan, Hainan, Hong Kong, Macao and Taiwan in China. Infected by Zika virus, fetus＇s neural system development is seriously damaged and causing microeephaly, nervous system growth retardation and even to fetal death in new born children. Envelope E protein, a kind of virus attachment protein （VAP） responsed for attachment of virus on host＇s cells which regulated by Toll-like receptor （TLR） by mediating cell signal pathway of zika virus which lead to pathological changes of nervous system. The purpose of the present article is to summary the etiology, global spreads of zika virus, the adaptive habitats of its vector Aedes aegypti achieved in recent years.

关 键 词：寨卡病毒 病原学 神经细胞受体 信号通路 适生地 

分 类 号：Q421[生物学—神经生物学]