颊针对类风湿关节炎家兔镇痛效应特性的研究  

Relationship of time and analgesic effect of buccal acupuncture on rabbits with rheumatoid arthritis

作　　者：蒲瑞生 方晓丽[1] 杜小正[1] 颉旺军[1] 秦晓光[1] 苏成红 

机构地区：[1]甘肃中医药大学针灸推拿学院,甘肃730000 [2]甘肃省天水市中医医院

出　　处：《北京中医药大学学报》2016年第12期1048-1053,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.81260559)

摘　　要：目的观察颊针对类风湿关节炎家兔镇痛效应的特点,为颊针临床应用提供实验依据。方法 40只家兔随机分成正常组、模型组、体针组、颊针组,每组10只。采用卵清蛋白诱导关节炎兔模型。造模成功后,体针组家兔在双侧膝眼和足三里、颊针组家兔在颊针"膝"穴每天接受针刺治疗1次,连续10次。分别在治疗第1、4、7、10次测定针刺0、5、15、30、60、120、240 min时的热痛阈值。结果颊针与体针均有明显的镇痛效果。颊针治疗5 min即开始显示明显的镇痛效应,30min时到达峰值,60 min时镇痛效应开始下降,240 min时的痛阈值降到与0 min时相同。而体针在治疗15 min时开始显示明显镇痛效应,30 min时到达峰值,60 min时镇痛效应开始下降,但240min痛阈值仍高于0 min时的痛阈值。结论颊针镇痛效应具有明显的时效关系,其时效曲线与体针时效曲线相似,但颊针起效快于体针,效应持续时间短于体针,且颊针镇痛效应不随治疗次数的增加而变化。Objective To explore the relationship of time and analgesic effect of buccal acupuncture on rabbits with rheumatoid arthritis （RA）,so as to provide the experimental basis for the clinical practice of buccal acupuncture.Methods Altogether 40 rabbits were randomly divided into normal group,model group,body acupuncture group and buccal acupuncture group （each n =10）.RA model was induced by subcutaneous injection of ovalbumin.After modeling,rabbits of body acupuncture group were needled at the acupoint of bilateral “Xiyan”and “Tsusanli”and those of buccal acupuncture group were needled at the buccal acupoint of “knee”once daily for ten times.Heat pain threshold at the time point of 0,5, 15,30,60,120,and 240 minutes were recorded at the 1 st ,4th ,7 th ,and 10th treatment.Results The buccal acupuncture and body acupuncture both showed definite analgesia effect.The heat pain threshold of buccal acupuncture group began to increase after five-minute treatment,reached the peak value at the 30th minute,then declined at the 60th minute to the same as that before treatment at the 240th minute.The variation trend of heat pain threshold of body acupuncture group was in common with that of buccal acu-puncture group,but the pain threshold at the 240th minute was higher than that before treatment.Con-clusion Buccal acupuncture against pain showed obvious effect-time relationship which was as similar as that of body acupuncture,but the onset time of buccal acupuncture was shorter than that of body acu-puncture,and the duration was shorter.Furthermore,the analgesic effect of buccal acupuncture showed no relationship with times.

关 键 词：颊针 镇痛效应 时效曲线 家兔 

分 类 号：R285.5[医药卫生—中药学]