镇肝熄风汤对糖尿病合并脑梗死患者急性期IL-6,TNF-α的影响  

Effects of Zhengan Xifengtang on IL-6 and TNF-α in Patients with Diabetes Mellitus Complicated with Acute Cerebral Infarction

作　　者：解晓静[1] 邢兆宏[1] 朱宏勋[1] 安丽[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中国实验方剂学杂志》2017年第2期159-163,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市中医管理局重点专科项目(ZZ-2012-19)

摘　　要：目的:观察镇肝熄风汤对糖尿病合并脑梗死急性期患者白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响及机制。方法:糖尿病合并脑梗死发病72 h内的80例患者,随机分为治疗组和对照组,各40例。治疗组在对照组治疗的基础上,口服中药镇肝熄风汤。治疗前后第7,14天观察两组中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分及IL-6,TNF-α水平。结果:治疗后治疗组中医症状的改善优于对照组(P<0.05)。治疗组NIHSS评分低于对照组(P<0.05)。两组患者治疗后7 d IL-6,TNF-α的水平均降低,治疗组明显低于对照组(P<0.05);治疗后14 d两组IL-6,TNF-α水平无明显差异。结论:镇肝熄风汤能够显著改善糖尿病合并脑梗死急性期患者的中医症状及神经功能缺损情况,减轻急性脑梗死的炎性反应。Objective： To observe the effects of Zhengan Xifengtang on interleukin-6（ IL-6） and tumor necrosis factor-α（ TNF-α） in patients with diabetes mellitus complicated with acute cerebral infarction,and investigate its mechanism of action. Method： The 80 patients within 72 h of diabetes mellitus with cerebral infarction were randomly divided into treatment group（ 40 cases） and control group（ 40 cases）. Patients in treatment group orally took Zhengan Xifengtang on the basis of treatment in control group. Traditional Chinese medicine（ TCM） syndrome scores and national institutes of health stroke scale（ NIHSS） scores were recorded and the serum levels of IL-6 and TNF-α were detected at different stages of treatment（ day 0,day 7 and day 14）.Result： The improvement of TCM symptoms in treatment group was significantly better than that in control group after treatment（ P〈0. 05）. The NIHSS scores of treatment group were significantly lower than those of control group after treatment（ P〈0. 05）. On day 7 after treatment,the levels of IL-6 and TNF-α were decreased in both groups,and the levels in treatment group were significantly lower than those in control group（ P〈0. 05）. There was no significant difference in the levels of and TNF-α between two groups on day 14 after treatment. Conclusion：Zhengan Xifengtang can significantly improve TCM symptoms and neurological deficits of patients with diabetes mellitus complicated with acute cerebral infarction and reduce the inflammatory response.

关 键 词：糖尿病 脑梗死 镇肝熄风汤 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R287[医药卫生—中药学]