预防儿童抗生素相关性腹泻的益生菌随机对照试验meta分析  

Effect of probiotics on prevention of antibiotic-associated diarrhea in children:a meta-analysis of randomized controlled trials

作　　者：何心[1] 张永[1] 许静[1] 王绚[1] 徐进[1] 

机构地区：[1]南京医科大学附属南京儿童医院,江苏南京210008

出　　处：《中华医院感染学杂志》2017年第1期185-189,共5页Chinese Journal of Nosocomiology

基　　金：江苏省药学会生物药学基金(2014012)

摘　　要：目的评价益生菌对预防儿童抗生素相关性腹泻发生情况的影响。方法检索Pubmed、EMbase、The Cochrane Library、万方数据库、维普资讯网以及中国知网全文数据库;纳入在儿童患者中研究预防性使用益生菌对抗生素相关性腹泻发病率影响的随机对照试验,并进行meta分析。结果筛选符合纳入标准的随机对照试验8项,患儿共1 880例;meta分析结果显示,与安慰剂组相比,预防性使用益生菌可降低儿童抗生素相关性腹泻的发病率(RR=0.32,95%CI=0.24~0.43)、艰难梭菌感染相关性腹泻的发病率(RR=0.37,95%CI=0.15~0.91),缩短平均腹泻持续时间(MD=-1.77,95%CI=-2.03^-1.51),减少患儿日均腹泻次数(MD=-0.19,95%CI=-0.38^-0.01)。结论预防性使用益生菌能够降低儿童抗生素相关性腹泻及艰难梭菌感染相关性腹泻的发病率,缩短腹泻持续时间以及减少日均腹泻次数。OBJECTIVE To evaluate the effect of probiotics on prevention of antibiotic-associated diarrhea in chil- dren. METHODS The following databases, Pubmed, EMbase, The Cochrane Library, Wanfang, VIP, and CNKI, were retrieved, the randomized controlled trials for the effect of prophylactic use of probiotics on morbidity rate of antibiotic-associated diarrhea in the children were included in the study. RESULTS Totally 8 randomized controlled trials were eligible and included in the study, involving 1 880 children. The result of the meta-analysis showed that as compared with the placebo group, the prophylactic use of probiotics could reduce the morbidity rates of antibiot- ic-associated diarrhea （RR = 0.32,95% CI = 0.24 - 0.43） and Clostridium difficile infection-associated diarrhea （RR=0.37,95%CI= O. 15-0.91）, shorten the mean duration of diarrhea （MD= --1.77,95% CI= --2.03 - -1.51）, and reduce the frequency of daily diarrhea （MD= -0. 19,95% CI= -0. 38%- -0. 01）. CONCLUSION The prophylactic use of probiotics can reduce the morbidity rates of antibiotic-associated diarrhea and C. difficile infection-associated diarrhea, shorten the duration of diarrhea, and reduce the frequency of daily diarrhea.

关 键 词：益生菌 抗生素相关性腹泻 儿童 META分析 

分 类 号：R725.7[医药卫生—儿科]