中药抗高血压药理学研究现状与展望  

Current situation and prospect of antihypertensive pharmacology of traditional Chinese medicine

作　　者：吕圭源[1] 苏洁[1] 陈素红[2] 

机构地区：[1]浙江中医药大学药物研究所,浙江杭州310053 [2]浙江工业大学长三角绿色制药协同创新中心,浙江杭州310014

出　　处：《中国药理学与毒理学杂志》2016年第12期1301-1311,共11页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81274123);浙江省重点研发计划项目(2016C03G2120164);浙江省重点实验室(2012E10002)~~

摘　　要：高血压病的发病率和增长率很高,病理病机复杂不清,严重危害人类健康。目前,高血压病无法根治,现用于治疗高血压病的化学药降压疗效显著,但需终身应用和需多药合用,也有明显不良反应,而降低高血压并发症作用不显著。中药有中医理论指导,在降压的同时能改善代谢异常,降低并发症和预后甚优,其优势或潜能尚未充分发挥,临床应用尚少。代谢性高血压已成为高血压病主体,其形成机制主要涉及代谢异常相关胰岛素抵抗和代谢性炎症等始动病理机制。系统阐述中药抗高血压药理学研究等现状、尤其代谢性高血压模型的研制与应用,对开展中药治疗高血压、尤其治愈高血压的新探索具有十分重要的意义。The incidence and its growth rate of hypertension are both very high. Its pathology and pathogenesis are complex and unclear,and it does serious harm to human health. Hypertension remains incurable. Chemical medicine has good effect on hypertension,but life- long application and multi- drug combination are required,with significant adverse reactions. Also,complications can′t be effectively alleviated. Traditional Chinese medicine （TCM） guided by traditional theories,can lower blood pressure,improve metabolic abnormalities and reduce complications. Its advantages or potentials have not been fully exploited and clinical application is inadequate. Metabolic hypertension has become the main form of hypertension,and its formation mechanism is mainly related to metabolic abnormalities and insulin resistance,metabolic inflammation and other pathology and pathogenesis. A better understanding of the current status of antihypertensive pharmacology of TCM,especially development and application of metabolic hypertension models is of great significance for TCM treatment of hypertension,and for exploration of new approaches to hypertension.

关 键 词：高血压 中药 药理学 代谢性高血压 动物模型 

分 类 号：R285[医药卫生—中药学]