细胞融合引发的衰老及其分子机制研究  

Study on Senescence Induced by Cell-cell Fusion and Its Mechanisms

作　　者：井敏敏 刘旭功 范欣[2,3] 陶瑞[2,3] 井申荣[1,2] 孙鹥[2,3] 

机构地区：[1]昆明理工大学医学院,中国云南昆明650500 [2]昆明理工大学附属昆华医院检验科,中国云南昆明650500 [3]云南省第一人民医院检验科,中国云南昆明650500

出　　处：《生命科学研究》2016年第6期561-564,共4页Life Science Research

基　　金：国家自然科学基金(81100377);云南省应用基础研究项目(2013FB203,31060155);昆明理工大学传染病流行病学与分子诊断省创新团队(2015HC030)

摘　　要：细胞融合引发的衰老普遍存在于发育正常的胚胎中,通常由特定的内源性逆转录病毒介导产生,其在生理和病理等方面起关键作用,例如:胚胎发育、免疫应答、肿瘤抑制及组织修复等。细胞融合引发的衰老异常不仅可导致胚胎疾病,还可引发正常组织癌变。目前,细胞融合引发衰老的潜在分子机制仍不清楚。现主要就国内外对于融合引发衰老的引发因素、表型特征、功能特征、相关分子机制及其潜在的应用价值等的研究进行综述。Senescence triggered by cell-cell fusion is common in placenta of normal development,which is usually mediated by a specific group of endogenous retroviruses.Cell-cell fusion induced senescence plays critical roles in multi-facets of pathophysiology,for instance,mammalian embryonic development,immune responses,tumor suppression and tissue reparation.In addition,the abnormal expression of fusion induced senescence can not only lead to embryonic diseases,but also lead to the malignant transformation of normal tissues.Nevertheless,the underlying molecular mechanisms of cell-cell fusion induced senescence are still unclear.Here,the initiation factors,phenotypic characteristics,functional characteristics,regulatory path-ways and the potential application of the cell-cell fusion induced senescence are described.

关 键 词：细胞融合 细胞衰老 融合引发衰老 表型特征 分子机制 

分 类 号：R392.2[医药卫生—免疫学]