法半夏对离体蟾蜍心功能的研究  

Effects of rhizoma pinellinae praeparata on isolated frog hearts

作　　者：霍雯[1] 蒲大力 吴明娟[2] 王云鹏[2] 李强[2] 吴珏蓉 陈林[2] 汪霞[2] 张建武[3] 

机构地区：[1]川北医学院机能实验中心 [2]川北医学院临床医学系 [3]川北医学院药理教研室,四川南充637100

出　　处：《四川生理科学杂志》2016年第4期195-197,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:观察法半夏悬浊液对离体蟾蜍心脏的心率和心肌收缩力的影响。方法:根据斯氏蛙心插管的方法,用0.033g·ml^(-1)、0.067g·ml^(-1)、0.133g·ml^(-1)和0.267g·ml^(-1)的法半夏悬浊液对离体蟾蜍心脏灌流,采用BL-420生物实验系统记录心率和心肌收缩力的变化。结果:灌注0.033g·ml^(-1)的法半夏悬浊液对离体蟾蜍心的收缩力和心率影响不大;分别灌注0.067g·ml^(-1)、0.133g·ml^(-1)和0.267g·ml^(-1)的法半夏悬浊液,离体蟾蜍心收缩力明显增强,心率减慢(P<0.05)。结论:法半夏可以增强离体蟾蜍心的收缩力,对其心率影响不大。Objective：To observe the effect of rhizoma pinellinae praeparata on heart rate and myocardial contractility of isolated frog heart.Methods：The Steinmann′s frog heart perfusion method was used to perfuse the isolated frog heart with different concentrations（0.033g·ml^-1,0.067g·ml^-1,0.133g·ml^-1 and 0.267g·ml^-1）of rhizoma pinellinae praeparata,then the changes of heart rate and myocardial contractility were recorded by the BL-420 Ebiological function experiment system.Results：Perfusion with0.033g·ml^-1 rhizoma pinellinae praeparata suspension had little effect on isolated toad heart contractility and heart rate.But perfusion with 0.067g·ml^-1,0.133g·ml^-1 and 0.267g·ml^-1 rhizoma pinellinae praeparata suspension significantly increased cardiac contractility,and decreased heart rate,respectively.Conclusion：Rhizoma pinellinae praeparata can enhance the isolated toad heart contractility,has little effect on heart rate.

关 键 词：法半夏 离体蟾蜍心 心率 心肌收缩力 

分 类 号：R285.5[医药卫生—中药学]