MRI定量分析颈动脉粥样硬化斑块脂质坏死核:与手术病理对照  

MRI quantitative analysis of lipid-rich necrotic core of carotid atherosclerotic plaque:Compared with histopathology

作　　者：尹安雨 张娜[2] 何品[1] 夏军[1] 

机构地区：[1]深圳市第二人民医院深圳大学第一附属医院放射科,广东深圳518053 [2]中国科学院深圳先进技术研究院生物医学与健康工程研究所保罗.C.劳特伯生物医学成像研究中心,广东深圳518055

出　　处：《中国医学影像技术》2017年第1期21-24,共4页Chinese Journal of Medical Imaging Technology

基　　金：深圳市科技计划基础研究项目(JCYJ20130329111053590);深圳市科技计划技术攻关项目(JSGG20141020103440414)

摘　　要：目的探讨MRI定量分析颈动脉斑块内脂质坏死核心(LRNC)的准确性。方法对19例颈动脉内膜剥脱术(CEA)患者术前行MR颈动脉检查,于MRI图像和病理组织学切片上分别测量LRNC的大小,计算其所占总管壁面积的百分比,分析两者的相关性。结果共151个MRI图像层面与患者的病理组织学区域相匹配,MRI与组织学测得LRNC占总管壁面积的百分比分别为(20.64±9.03)%和(18.65±9.49)%,两者具有中-高度相关性(r=0.69,P<0.001)。结论MRI可定量测量颈动脉斑块内LRNC,有助于预测斑块的稳定性。Objective To explore the accuracy of MRI in the quantitative evaluation of lipid-rich necrotic core（LRNC） of carotid atherosclerotic plaque in vivo.Methods Nineteen patients were underwent carotid MRI before carotid endarterectomy（CEA）.MR images and histology specimens were reviewed for quantitative measurements of LRNC areas.Percentages of LRNC areas to the total vessel area were recorded to analyze the correlation between MR images and histology specimens.Results There were 151 MR images matched histology specimens.The mean percentages of LRNC areas measured by MRI and histology were（20.64 ＋ 9.03）%and（18.65 ＋ 9.49）%,which had moderate to strong correlation（r=0.69,P〈0.001）.Conclusion MRI can quantitatively measure the LRNC of carotid atherosclerotic plaque,which may be useful in predicting the risk of plaque.

关 键 词：颈动脉 斑块 粥样硬化 磁共振成像 病理学 

分 类 号：R543.4[医药卫生—心血管疾病] R445.2[医药卫生—内科学]