早期雾化吸入不同药物对全身麻醉气管插管下行妇科腹腔镜手术患者术后咽喉部不适的影响  

Effects of Early Aerosol Inhalation of Different Drugs on Throat Discomfort of Patients Underwent Gynecological Laparoscopic Operation under Endotracheal Intubation with General Anesthesia

作　　者：白玲[1] 吴洁[2] 

机构地区：[1]山西医科大学第二医院麻醉科,山西太原030001 [2]上海市第一人民医院麻醉科,上海200080

出　　处：《解放军护理杂志》2016年第21期29-32,共4页Nursing Journal of Chinese People's Liberation Army

基　　金：山西省科技攻关项目资助(20150313010-7);山西医科大学第二医院护理基金资助(20140301)

摘　　要：目的比较妇科腹腔镜手术气管插管患者入麻醉恢复室后即刻雾化吸入不同药物对术后咽喉部不适的改善情况。方法便利抽样选取200例妇科腹腔镜手术患者作为研究对象,按随机单盲对照实验设计要求分为四组:A组(呋塞米),B组(布地奈德),C组(氨溴索)及D组(生理盐水,对照组),每组各50例。各组患者于术后进入麻醉恢复室即刻雾化吸入相应药物,并于入室即刻(雾化前)、雾化吸入结束后即刻、雾化后6h、12h、24h、36h、48h、72h、96h对四组患者进行咽喉部不适(咽喉疼痛、声音嘶哑、咽部异物感)评估并记录分值。结果 A、B、C组患者的咽喉疼痛评分在雾化吸入后36h低于D组,在雾化吸入后即刻到吸入后24h各时点的声音嘶哑评分低于D组,差异均有统计学意义(均P<0.05);咽部异物感的评分结果显示,A组与C组在雾化后即刻、雾化后12h、36h和48h记录点的评分低于D组,而B组在雾化后36h和48h记录点的评分低于D组,差异均有统计学意义(均P<0.05)。结论气管插管术后即刻雾化吸入布地奈德、呋塞米、氨溴索均可在缓解患者术后咽喉疼痛、声音嘶哑、咽部异物感等咽喉部不适方面取得确切的疗效,但在缓解咽喉异物感方面,呋塞米、氨溴索的作用优于布地奈德,其机制尚待进一步研究。Objective To study the effect of early aerosol inhalation of different drugs on throat discomfort of patients underwent gynecological laparoscopic operation under endotracheal intubation with general anesthesia.Methods By convenience sampling, 200 cases were selected and divided into group A （Furosemide）, group B （Budesonide）, group C （Ambroxol） and group D （saline,control group ）,with 50 cases in each group.Patients had aerosol inhalation of drugs after entering into postanesthesia care unit （PACU）, and the throat discomfort （throat paih,hoarseness and pharyngeal foreign body sensation） before entering into PACU,after aerosol inhalation,and 6 h, 12 h,24 h,36 h,48 h, 72 h,96 h after aerosol inhalation were analyzed,and the results were recorded.Results The pain scores in groupA,B, C 36 hours after aerosol inhalation were lower than group D.The scores of hoarseness at the time points from the time after aerosol inhalation to 24 h after aerosol inhalation were lower than group D （all P〈0.05）,The pharyngeal foreign body sensation scores showed that the score of the time right after aerosol inhalation,12 h,36 h,and 48 h in group A and C were lower than group D,while the scores at 36 h and 48 h in group B were lower than group D （all P〈0.05）. Conclusions The Furosemide, Budesonide and Ambroxol can alleviate the postoperative throat pain, hoarseness and pharyngeal foreign body sensation.In the casing of easing the discomfort of pharyngeal foreign body sensation, the Furosemide and Ambroxol has better effects than Budesonide,the mechanism requires further study.

关 键 词：全身麻醉 气管插管 雾化吸入 布地奈德 氨溴索 呋塞米 咽喉部不适 

分 类 号：R472.3[医药卫生—护理学]