原发性开角型青光眼房水蛋白含量的检测及其与中医证型关系的研究  

Study on the Relationship Between the Contents of Aqueous Humor Protein in Patients with Primary Open Angle Glaucoma and the TCM Syndrome Types

作　　者：彭俊[1] 李建超[1,2] 姚小磊[1] 曾志成 徐剑 江冰[4] 彭抿 彭清华[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南省郴州市第一人民医院眼科,湖南郴州420000 [3]湖南省桂阳县人民医院眼科,湖南郴州430000 [4]中南大学湘雅二医院眼科,湖南长沙410006 [5]湖南省长沙星沙人民医院眼科,湖南长沙410600

出　　处：《湖南中医药大学学报》2016年第12期31-33,共3页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金资助项目(81273807;81403437);教育部博士学科点基金资助项目(20124323110006);湖南省自然科学基金重点资助项目(11JJ2050);湖南省教育厅科研基金重点资助项目(06A052;10A094);湖南省研究生创新基金重点资助项目(CX2013A013);中医诊断学国家重点学科开放基金重点项目(2014-06);湖南省高层次卫生人才"225"工程培养项目资助;国家中医药管理局中医眼科学重点学科建设项目;湖南省中医五官科学重点学科建设项目

摘　　要：目的探讨原发性开角型青光眼患者眼房水蛋白含量的改变及其与中医辨证分型之间的关系。方法采用溴甲酚绿比色法对128例128只眼原发性开角型青光眼和64例64只眼老年性白内障患者的房水蛋白进行了测定。结果开角型青光眼疾病分类各组及中医证型(肝郁气滞证、痰湿犯目证、肝肾阴虚证)各组均表现为房水白蛋白和总蛋白含量增高,与老年性白内障组相比,各组均有非常显著性差异(P<0.01)。开角型青光眼疾病分类组间比较及中医证型组间比较,房水白蛋白和总蛋白含量亦均有显著性差异(P<0.05)或非常显著性差异(P<0.01)。结论原发性开角型青光眼患者的血-房水屏障功能遭到破坏,房水的粘度增加,房水淤积于眼内。Objective To explore the relationship between the protein content in aqueous humor of patients with primary open angle glaucoma and the TCM Syndrome Types. Methods The aqueous humor protein in 128 cases of primary open angle glaucoma and 34 cases of senile cataract patients was measured by bromocresol green eolorimetric method. Results The aqueous humor albumin and total protein were increased from open angle glaucoma disease classification groups and the TCM syndrome types （liver depression and Qi stagnation syndrome, phlegm-damp invading the eyes syndrome, liver-kidney Yin deficiency syndrome）, compared with the age-related cataract group, each group was statistically significant （P〈0.01）. There were significant differences in the levels of albumin and total protein in the patients with open angle glaucoma and TCM syndrome types （P〈0.05 or P〈0.01）. Conclusion The blood aqueous barrier function in patients with primary open angle glaucoma was destroyed, the viscosity of aqueous humor increased, and the aqueous humor was deposited in the eyes.

关 键 词：青光眼 开角型 房水蛋白 肝郁气滞证 痰湿犯目证 肝肾阴虚证 

分 类 号：R276.7[医药卫生—中医五官科学]