益气解毒法对胃癌术后辅助化疗患者生存质量的影响  

Effects of Yiqi Jiedu Method as Postoperative Adjuvant Chemotherapy on the Quality of Life of Patients with Gastric Cancer

作　　者：王常松[1] 林圣远[2] 谢春婷 林昆明[4] 

机构地区：[1]福建中医药大学中医学院,福建福州350122 [2]福建医科大学附属第一医院,福建福州350122 [3]福建省肿瘤医院,福建福州350122 [4]福建省第二人民医院体检中心,福建福州350122

出　　处：《湖南中医药大学学报》2016年第12期55-59,共5页Journal of Hunan University of Chinese Medicine

摘　　要：目的观察益气解毒法对胃癌术后辅助化疗患者生存质量的影响。方法 50例胃癌术后采用替吉奥和奥利沙铂(SOX方案)进行辅助化疗患者(观察组),配以益气解毒法中医治疗2个化疗周期,观察化疗药物的毒副反应、Karnofsky评分和QLQ-30评分,并与50例胃癌术后单用SOX方案进行辅助化疗患者(对照组)进行比较。结果毒副反应:在贫血、恶心呕吐、周围神经毒性、口腔黏膜损害和肝功能损害方面,观察组级别明显低于对照组(P<0.05);Karnofsky评分:观察组Karnofsky评分优于对照组(P<0.05);QLQ-30评分:对照组治疗前后疲乏无力、恶心呕吐和食欲减退的评分较治疗前显著升高(P<0.05),观察组治疗后情绪功能和整体生活质量评分较治疗前显著升高(P<0.05),其余各项目治疗前后评分差异无统计学意义(P>0.05)。结论益气解毒法可减轻胃癌术后辅助化疗毒副反应,提高患者生存质量。Objective To observe the effects of Yiqi Jiedu method as postoperative adjuvant chemotherapy on the quality of life （QOL） of gastric cancer patients. Methods Fifty patients with gastric cancer after surgery （the observation group） were received adjuvant chemotherapy with S-1 plus oxaliplatin （SOX） and Yiqi Jiedu method for 2 cycles of chemotherapy. The 50 cases of gastric cancer patients as control group after surgery were only received adjuvant chemotherapy with SOX. The changes of side effects of chemotherapy drugs, Karnofsky and QLQ-30 of two groups were observed and compared. Results The levels of anemia, nausea and vomiting, peripheral neurotoxicity, oral mucosal damage and liver damage of the observation group were significantly lower than that of the control group （P〈0.05）. The level of Karnofsky in the observation group was superior to the control group （P〈0.05）. The QLQ-30 score of fatigue, nausea and vomiting and poor appetite in the control group after treatment were significantly higher than that before treatment （P〈0.05）, and the score of emotional functioning and global health in the observation group after treatment were significantly higher than that before treatment （P〈0.05）. The other indicators of the two groups before and after treatment showed no significant difference （P〉0.05）. Conclusion Yiqi Jiedu method as postoperative adjuvant chemotherapy can reduce side effects of chemotherapy drugs, and improve the quality of life of patients with gastric cancer after surgery.

关 键 词：益气解毒法 胃癌术后化疗 SOX方案 生存质量 

分 类 号：R256.3[医药卫生—中医内科学]