实时超声弹性定量参数与肝纤维化分期的相关性  

The Correlation between Quantitative Parameters of Real-Time Ultrasound and Liver Fibrosis Stage

作　　者：郭静文[1] 陈越峰[1] 周瑞莉[1] 李妙珊[1] 郭汉涛[1] 

机构地区：[1]广东省人民医院影像医学部超声科广东省医学科学院,广州510080

出　　处：《循证医学》2016年第6期352-354,361,共4页The Journal of Evidence-Based Medicine

摘　　要：目的探索实时超声弹性定量参数与肝纤维化分期的相关性,筛选与纤维化程度密切相关的定量参数。方法对106例慢性乙型肝炎患者行组织弥散定量分析检查,得出定量参数,并与肝纤维化病理分期进行比较。用Spearman秩相关分析定量参数与肝纤维化分期的关系,用受试者工作特性曲线下面积分析各参数的诊断价值。结果 Spearman秩相关分析显示,在获得的11个弹性定量参数中,应变均值(MEAN)、蓝色领域百分比(AREA)与肝纤维化病理分期相关性最高,分别为-0.79、0.84(P<0.01)。实时组织弹性图像评分为F0、≥F1、≥F2、≥F3、F4时MEAN和AREA的受试者工作特性曲线下面积分别为0.92、0.93,0.93、0.92,0.93、0.91,0.91、0.94,0.94、0.94。结论实时超声弹性定量参数可评估肝纤维化的程度,AREA、MEAN与肝纤维化病理分期相关性最高。MEAN和AREA各期受试者工作特征曲线下面积均>0.90,对肝纤维化分期的诊断价值较高。Objective To explore the correlation between quantitative parameters of real-time ultrasound and liver fibrosis stage, and to screen the quantitative parameters closely related to the degree of fibrosis. Methods The quantitative parameters were obtained from 106 patients with chronic hepatitis B, and compared with the pathological staging of liver fibrosis. The relationship between quantitative parameters and liver fibrosis stage was analyzed by Spearman rank correlation analysis, the diagnostic value was analyzed by ROC curve analysis. Results Spearman rank correlation analysis showed that the correlation coefficients of AREA and MEAN were the largest in the eleven elastic quantitative parameters, and were -0.79, 0.84 （P〈0.01）, image real-time tissue elasticity score was F0, greater than or equal to F1, greater than or equal to F2, greater than or equal to F3, and F4, ROC area under the MEAN and AREA were 0.92, 0.93 ; 0.93, 0.92; 0.93, 0.91 ; 0.94, 0.94. Conclusion Real-time ultrasonic quantitative parameters can be used to evaluate the degree of liver fibrosis. The correlation between AREA and MEAN and the pathologic stage is the most significant, thus indicating good diagnostic value. The ROC area under the MEAN and AREA were larger than 0.9, and the diagnosis value of liver fibrosis stage was high.

关 键 词：超声弹性成像 组织弥散定量分析 肝纤维化 

分 类 号：R445.1[医药卫生—影像医学与核医学]