敞开式离子化质谱及其在体内药物分析中的应用  

Ambient mass spectrometry and its application in biopharmaceutical analysis

作　　者：龚欢[1] 葛庆华[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《药物分析杂志》2017年第1期1-12,共12页Chinese Journal of Pharmaceutical Analysis

摘　　要：敞开式离子化质谱是近十年来逐渐新兴的一种无需对样品进行复杂前处理或色谱分离,在常温常压环境下直接通过质谱分析样品中痕量物质信息的新型质谱技术。该技术极大地提高了质谱分析效率,使得原位实时快速分析样品成为可能并在食品安全、环境监测、生物医药等领域得到广泛应用。本文系统综述包括解吸电喷雾电离、纸喷雾电离、实时直接分析等典型敞开式离子化质谱的基本原理与操作方法,述评各技术在体内药物分析领域的典型应用,并展望敞开式离子化质谱技术的应用前景。Ambient mass spectrometry has evolved as a novel type of mass spectrometry techniques in the past decade, which is used to analyze the trace substance in the sample directly under normal temperature and pressure without any complicated pretreatment or chromatographic separation. With high efficiency and low expense, this technology has acquired widespread applications in food safety, environmental surveillance, bioanalysis and other fields. In this paper, the mechanisms and manipulations of typical ambient ionization techniques in details, such as desorption electrospray ionization, paper spray ionization and direct analysis in real time, are summarized. Furthermore, the applications in biopharmaceutical analysis are reviewed.

关 键 词：敞开式离子化质谱 电喷雾电离 纸喷雾电离 实时直接分析 大气压固态分析探针 解吸大气压化学电离 体内药物分析技术 进展 

分 类 号：R917[医药卫生—药物分析学]