红花注射液联合前列地尔和西地那非治疗慢性肺心病的肺动脉高压  

Safflower Injection combined with alprostadil and sildenafil treats the chronic pulmonary heart disease complicated with pulmonary hypertension

作　　者：杨铁骊[1] 张小方[1] 潘胜军[1] 陈昆[1] 从静[1] 

机构地区：[1]黄淮学院附属医院,河南驻马店463000

出　　处：《中成药》2017年第1期40-46,共7页Chinese Traditional Patent Medicine

摘　　要：目的观察红花注射液(红花黄色素)联合前列地尔和西地那非治疗慢性肺源性心脏病(慢性肺心病)肺动脉高压的疗效。方法将223例慢性肺心病肺动脉高压患者随机分为2组,对照组111例在常规治疗基础上加用前列地尔和西地那非,治疗组112例在对照组基础上加用红花注射液,观察2组疗效和药物副作用。结果治疗组总有效率显著高于对照组。2组肺动脉收缩压(SPAP)、肺动脉平均压(m PAP)及肺动脉舒张压(DPAP)较治疗前显著降低,左室射血分数(LVEF)较治疗前显著升高;治疗组治疗后SPAP、m PAP和DPAP较对照组治疗后显著降低,LVEF显著升高。2组动脉血氧分压(Pa O2)和动脉血氧饱和度(Sa O2)较治疗前显著升高,二氧化碳分压(Pa CO2)较治疗前显著降低;治疗组治疗后Pa O2较对照组治疗后显著升高。2组全血黏度高切、全血黏度低切、血浆黏度、红细胞压积和血小板聚集率较治疗前显著降低;治疗组治疗后全血黏度高切、全血黏度低切、血浆黏度和血小板聚集率较对照组治疗后显著降低。2组高敏C反应蛋白(hs-CRP)、磷酸肌酸激酶同工酶(CK-MB)和肌钙蛋白I(Tn I)较治疗前显著降低;治疗组治疗后hs-CRP、CK-MB和Tn I较对照组治疗后显著降低。2组不良反应发生率无差异,2组治疗前后肝肾功能无明显变化。结论红花注射液联合前列地尔和西地那非治疗慢性肺心病肺动脉高压疗效较好。AIM To observe the effect of Safflower Injection（ safflower yellow） combined with alprostadil and sildenafil in the treatment of chronic pulmonary heart disease（ chronic cor pulmonale） complicated with pulmonary hypertension. METHODS Two hundred and twenty-three cases of chronic pulmonary heart disease complicated with pulmonary hypertension patients were randomly divided into two groups,the control group of one hundred and eleven cases in conventional therapy plus alprostadil and sildenafil,one hundred and twelve cases in the treatment group were treated with Safflower Injection on the basis of the control group. The efficacy and side effects in two groups were observed. RESULTS The total effective rate of the treatment group was significantly higher than that of the control group. Pulmonary artery systolic pressure（ SPAP）,pulmonary arterial mean pressure（ m PAP） and pulmonary artery diastolic blood pressure（ DPAP） in two groups,compared with those before the treatment,were significantly decreased,left ventricular shoot ejection fraction（ LVEF）,compared with those before treatment,was significantly increased; SPAP,m PAP and DPAP of treatment group after the treatment were decreased significantly as compared with the control group,LVEF was significantly increased. Arterial partial pressure of oxygen（ PaO2）and arterial oxygen saturation（ SaO2） in two groups,compared with those before the treatment,were significantly increased,carbon dioxide partial pressure（ PaCO2）,compared with those before the treatment,was significantly decreased; after treatment in the treatment group,PaO2 was significantly increased as compared with the control group. Blood high shear viscosity,whole blood viscosity at low shear,plasma viscosity,red blood cell pressure volume and platelet aggregation rate in two groups were significantly lower than those before the treatment; whole blood high shear viscosity,whole blood viscosity of low shear,plasma viscosity and platelet aggregation rate in the treatment g

关 键 词：红花注射液 前列地尔 西地那非 慢性肺心病 肺动脉高压 

分 类 号：R287[医药卫生—中药学]