宽筋藤对类风湿性关节炎模型大鼠踝关节组织病理学的影响  

Effects of Caulis Tinosporae sinensis on Histopathology of Ankle Tissue in Rheumatoid Arthitis Rats

作　　者：曾聪彦[1] 吴凤荣[1] 戴卫波[1] 高玉桥[1] 梅全喜[1] 

机构地区：[1]广州中医药大学附属中山中医院,中山528400

出　　处：《天然产物研究与开发》2017年第1期147-151,共5页Natural Product Research and Development

基　　金：广东省中山市科技计划(2014A1FC138)

摘　　要：为了观察宽筋藤对弗氏完全佐剂(CFA)诱导的佐剂性关节炎(AA)大鼠踝关节组织病理改变的影响,除正常组外,其余各组大鼠足跖皮内注射CFA致AA大鼠模型,将模型大鼠随机分成模型组、宽筋藤高剂量组、宽筋藤中剂量组、宽筋藤低剂量组、阳性药物组,灌胃给药20 d,观察各组大鼠继发侧足爪肿胀度及踝关节滑膜、软骨、关节腔、周围软组织炎症反应等组织病理改变情况,进行综合评分。实验结果表明,与模型组比较,宽筋藤能减轻AA大鼠关节肿胀程度,并显著抑制炎症细胞的浸润和滑膜增生以及血管翳的形成,减轻软骨及骨质损伤程度(P<0.05或P<0.01)。实验证明,宽筋藤可显著改善AA大鼠关节组织病理改变。The objective of study was to observe the effect of Caulis Tinosporae sinensis on pathological changes of ankle tissue in rats with adjuvant arthritis （AA） which are induced by Freund＇s complete adjuvant （CFA）.Except for the normal control group,all rats were injected CFA through plantar subcutaneous injection to induce the AA,Rats with AA were randomly divided into five groups：model group,high,middle and low-dose Caulis Tinosporae sinensis group,positive control group.The rats in each group were respectively treated with corresponding medicine for 20 days.Secondary foot claw degree of swelling was examined by vlume method.The ankle tissue was examined under microscope to evaluate the pathological changes of synovium,cartilage and articular cavity as well as soft tissue inflammation.The experimental results showed that Caulis Tinosporae sinensis can reduce secondary foot claw degree of swelling and significantly inhibit the hyperplasia of synovial membrane and the infiltration of inflammatory cells and the formation of pannus,and reduce cartilage injury as compared with the model group （P〈0.05;P〈0.01）.Finally,it was concluded that Caulis Tinosporae sinensis can significantly inhibit pathological changes of ankle tissue in rats with AA.

关 键 词：宽筋藤 佐剂性关节炎 组织病理学 

分 类 号：R285.5[医药卫生—中药学]