胰岛素与榄香烯在葡萄糖注射液中的配伍稳定性考察  

Compatible Stability of Insulin Injection Mixed with Elemene Injection in Glucose Infusions

作　　者：彭家志[1] 何争民 

机构地区：[1]安徽省合肥市第二人民医院,安徽合肥230001

出　　处：《中国药业》2017年第1期13-15,共3页China Pharmaceuticals

摘　　要：目的考察10%葡萄糖注射液中榄香烯和胰岛素配伍后的稳定性。方法在室温、自然光下、12 h内,考察榄香烯-胰岛素-10%葡萄糖配伍液的外观、p H变化,以及配伍液中不溶性微粒的变化。采用高效液相色谱法考察配伍液中胰岛素含量的变化。结果配伍液在12 h内无浑浊、沉淀、气体产生,颜色、p H、不溶性微粒数等无明显变化,胰岛素含量无明显变化。结论在拟订实验条件下,胰岛素在10%葡萄糖注射液中与榄香烯配伍稳定。Objective To observe the compatibility of insulin and elemene for injection in 10% glucose infusions（GS）. Methods The changes in appearance, particles and pH of the mixture in 12 h at ambient temperature and natural light condition were observed. The concentration of insulin was determined by HPLC. Results No obvious changes in appearance, color, gas, precipitation, turbidity or the number of insoluble particles were shown. The content of insulin in 12 h was kept stable. Conclusion Insulin injection mixed with elemene injection in 10% GS is stable in 12 h under the testing conditions.

关 键 词：胰岛素 榄香烯 配伍 稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学] R979.1[医药卫生—药学]