二氢石蒜碱对家兔心室乳头肌及血管平滑肌收缩的影响  

Effects of dihydrolycorine on isolated papillary muscles of rabbit

作　　者：潘龙瑞[1] 蓝星莲[1] 于龙顺[1] 任世兰[1] 赵国举[1] 

机构地区：[1]郧阳医学院药理教研室,湖北十堰442000

出　　处：《郧阳医学院学报》2002年第3期136-138,共3页Journal of Yunyang Medical College

基　　金：湖北省自然科学基金资助课题 (No2 0 0J166)

摘　　要：目的 :观察二氢石蒜碱 (dihydrolycorine ,DL)对家兔心室乳头肌的作用。方法 :采用家兔离体右心室乳头肌(PM)、胸主动脉 (TA)及基底动脉 (BA)标本 ,记录药物对其张力的影响。结果 :DL或Nim对电刺激诱发PM的收缩均有剂量依赖性抑制作用 ,其IC50 值分别为 (1.4 5± 0 .89)× 10 -3 mol·L-1、(1.30± 0 .4 5 )× 10 -6mol·L-1;KCl(6 0mmol·L-1)、NA(0 .1mmol·L-1)所致TA及BA收缩 ,DL使之呈剂量依赖性松弛 ,其IC50 值对TA分别为 (2 .91± 0 .99)× 10 -3mol·L-1、(1.4 9± 0 .5 9)× 10 -3 mol·L-1;对BA分别为 (3.4 1± 1.5 2 )× 10 -3 mol·L-1、(6 .6 9± 3.12 )× 10 -4mol·L-1,DL拮抗NA所致基底动脉收缩作用明显强于KCl(P <0 .0 1)。Nim对KCl所致收缩的抑制显著强于对NA(P <0 .0 1) ;DL对电刺激诱发PM收缩的IC50 值低于KCl所致TA、BA收缩IC50 值 ,且显著高于NA所致BA收缩IC50 值 ,低于NA所致TA收缩IC50 值。结论 :DL对电刺激所致PM的收缩具有抑制作用 ,其作用机制可能为抑制PDC、ROC ,且抑制作用ROC >PDC。Objective To observe the effects of dihydrolycorine (DL) on isolated papillary muscles of rabbit.Methods The isolated papillary muscles and thoracicaorta(TA) and basilar artery(BA) preparations were made to record changes of tension induced by drugs.Results DL or Nim produced a concentration-dependent inhibition of the contraction response induced by electrical stimulation in PM,the IC 50 values were (1.45±0.98)×10 -3 mol·L -1 and (1.30±0.45)×10 -6 mol·L -1 .DL produced a contraction-dependent relaxation in KCl(60 mmol·L -1 ) or noradrenaline (NA,0.1 mmol·L -1 ) contracted TA and BA rings.The IC 50 values were (2.91±0.98)×10 -3 mol·L -1 and (1.49±0.59)×10 -3 mol·L -1 respectively about TA.The IC 50 values were (3.14±1.52)×10 -3 mol·L -1 and (6.69±3.12)×10 -4 mol·L -1 respectively about BA.IC 50 valuces of DL inhibited the contraction of the PM induced by electrical stimulation was less than that by KCl in TA or BA rings ( P <0.01).IC 50 values of DL inhibited the contraction of the PM induced by electrical stimulation were significantly greater than those by NA in BA rings ( P <0.01),but were less than those by NA in TA rings.Conclusions DL produced an inhibition of the contraction response induced by electrical stimulation in PM,The effect may inhibit PDC and ROC,with the inhibitive effect of ROC>PDC.

关 键 词：二氢石蒜碱 乳头肌 电刺激 兔 药理 

分 类 号：R285.5[医药卫生—中药学]