丝氨酸蛋白酶-Corin在妊娠期高血压疾病中应用的研究进展  

Advances in the application of serine protease-Corin in hypertensive disorder complicating pregnancy

作　　者：陈德新[1] 菅莹莹[2] 王瑜[2] 何荣霞[1] 

机构地区：[1]兰州大学第二医院产科,甘肃兰州730030 [2]兰州大学第二临床医学院,甘肃兰州730030

出　　处：《中国计划生育和妇产科》2017年第1期24-28,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：妊娠期高血压疾病在世界范围内长期对孕产妇及胎儿的健康及生命安全构成严重威胁,其发病机制至今仍不明确。近期的相关研究发现一种Ⅱ型跨膜丝氨酸蛋白酶—Corin不仅主要分布在心脏,参与A型利钠肽和B型利钠肽的调节,而且也表达于妊娠期子宫。其对孕早期子宫螺旋小动脉重铸能否顺利进行有着重要的作用。而这一过程与妊娠期高血压疾病的发生有密切关系。本文主要从丝氨酸蛋白酶-Corin的分子结构特征、组织分布、生物学功能等方面进行阐述,并对Corin的基因缺陷或蛋白的缺乏是否与妊娠期高血压疾病存在相关性,以及可能的参与机制做一综述,为该病的早期预测提供新的研究理论基础。Hypertensive disorder complicating pregnancy （HDCP） poses a serious threat to maternal and fetal＇s health and life safety around the world for a long time. However, its pathogenesis is still unclear. Recent studies found a Ⅱ transmembrane serine protease - Corin which is mainly distributed in the heart, not only to participate in the regulation of A type natriuretic peptide （ atrial natriuretic peptide, ANP） and B- type natriuretic peptide （brain natriuretic peptide, BNP） , but also expresses in the uterus during pregnancy. It plays an important role in the recasting of uterus spiral small arteries in early pregnancy. This process have a close relationship with the incidence of HDPC. This paper mainly expounds Corin characteristics of molecular structure, biological function, tissue distribution, which also introduces the correlation of Corin gene defect or protein deficiency with HDPC and possible mechanism of HDPC. This paper is likely to provide a new theoretical basis for the early prediction of the disease.

关 键 词：妊娠期高血压疾病 子痫前期 丝氨酸蛋白酶 CORIN 利钠肽 

分 类 号：R332[医药卫生—人体生理学]