235例细胞学阴性/高危型人乳头瘤病毒阳性患者宫颈病理结果分析  

Analysis of cervical pathology in 235 cytology-negative/HR-HPV positive patients

作　　者：王丽君[1] 张锦文[1] 成建[1] 吴江平[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院妇女保健科,江苏南京210004

出　　处：《中国计划生育和妇产科》2017年第1期59-63,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的了解宫颈细胞学和高危型人乳头瘤病毒(high risk-human papillomavirus,HR-HPV)联合检查的必要性。方法对2013年12月至2014年12月在南京医科大学附属南京妇幼保健院门诊进行妇科检查,细胞学阴性/HR-HPV阳性的235例患者进行阴道镜检查和宫颈活组织病理检查,对其结果进行分析。结果 235例患者中,85例感染HPV 16/18型,宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)≥Ⅱ级19例(22.35%);150例感染其余各型,≥CINⅡ的16例(10.67%),差异有统计学意义(P﹤0.05)。结论细胞学和HR-HPV联合检查提高了CIN和宫颈癌的检出率,HR-HPV16/18的检出更有助于识别那些处于最高风险患CIN的女性,更有利于对宫颈癌的早期发现和诊治。Objective To understand the necessity of the joint inspection of cervical cytology and high risk - human papilloma virus （HR- HPV）. Methods 235 cytology -negative/HR - HPV positive women who took gynecological examination in Nanjing Maternity and Child Health Hospital Affiliated Nanjing Medical University from December 2013 to December 2014 were selected. Colposcopy and cervical histopathological examination were carried out and the results were analyzed. Results In 235 cases ,85 cases were infected with HPV 16/18, and 19 cases （ 22.35% ） were found to have cervical intraepithelial neoplasia CIN ）Ⅱ - Ⅲ, 150 cases were infected with other HR - HPV types and 16 cases （ 10.67% ） were found to have CIN Ⅱ -Ⅲ. The difference was statistically significant （ P 〈 0.05 ）. Conclusion Joint inspection of cytology and HR - HPV improves the detection ratio of CIN and cervical cancer. The detection of HR - HPV 16/18 helps to recognize women with highest risk of CIN ,and is beneficial to discover and treat cervical cancer.

关 键 词：宫颈细胞学 高危型人乳头瘤病毒 基因型 宫颈上皮内瘤变 

分 类 号：R711.74[医药卫生—妇产科学]