维生素D在喘息性支气管炎发病中的作用  

Application of vitamin D in the attack of asthmatic bronchitis

作　　者：薛秀丽 池红井 冀楠 薛涵[4] 

机构地区：[1]河北省承德市妇幼保健院儿科,河北承德067000 [2]河北省承德市卫生和计划生育委员会信息中心,河北承德067000 [3]河北省隆化县镇医院,河北隆化068150 [4]河北省承德市中心医院,河北承德067000

出　　处：《河北医学》2016年第12期2068-2070,共3页Hebei Medicine

摘　　要：目的:探讨维生素D(Vit D)在儿童喘息性支气管炎发病中的作用。方法:喘息性支气管炎患儿96例随机分为Vit D治疗组及非Vit D治疗组,各48例;单纯支气管炎患儿40例设为单纯支气管炎组;选取同时期健康体检儿童30例设为对照组。观察4组儿童入院后治疗前或体检时血液1,25-(OH)2-D3、ALT、免疫球蛋白水平;观察治疗后Vit D治疗组及非Vit D治疗组上述指标,以及患儿症状、体征缓解情况,随访半年,记录咳嗽或哮喘再发次数。结果:喘息性支气管炎患儿平均1,25-(OH)2-D3水平显著低于对照组及单纯支气管炎组,ALP、Ig E水平均显著高于后2组(P<0.01)。治疗1个月后Vit D治疗组1,25-(OH)2-D3、ALP、Ig E改善程度显著优于非Vit D治疗组(P<0.01)。Vit D治疗组哮喘缓解时间、肺部体征消失时间、咳嗽或哮喘再发次数均显著低于非Vit D治疗组(P<0.01)。结论:喘息性支气管炎患儿体内Vit D缺乏。补充Vit D可调节患儿免疫系统功能,改善肺功能,减少患儿咳嗽或哮喘发作次数。Objective：To explore the application of vitamin D （ VitD） in the attack of asthmatic bron-chitis.Methods：A total of 96 children with asthmatic bronchitis were randomly divided into VitD treatment group and non-VitD treatment group, 48 cases in each group. 40 children with simple bronchitis were de-signed as simple bronchitis group and 30 healthy children at the corresponding period as control group. Re-sult：The levels of 1,25-（OH）2-D3, ALT and immune globulin of 4 groups before and after treatment after admission or at physical examination were observed. The symptoms and sings of patients were recorded. After follow-up of half a year, the frequency of cough and asthma were recorded. Results The level of 1,25-（ OH） 2-D3 of asthmatic bronchitis was significantly lower than that of control group and simple bronchitis group and the levels of ALP and IgE were higher than latter groups （P〈0.01）. The levels of 1,25-（OH）2-D3, ALP and IgE in VitD treatment group after treatment for 1 month improved significantly better than those in non--VitD treatment group（ P〈0.01） . The alleviation time of asthma, pulmonary symptoms disappearing time, reoc-currence of cough and asthma in VitD treatment group were obviously lower than those in non-VitD treatment group （ P〈0.01） . Conclusion：Children with asthmatic bronchitis are deficient in VitD, so the supplement of VitD can regulate the function of immune system, improve the function of the lung as well as reducing the at-tack of cough and asthma.

关 键 词：维生素D 喘息性支气管炎 儿童 

分 类 号：R725.6[医药卫生—儿科]