不同剂量缬沙坦对慢性肾炎合并高血压的疗效及安全性  

Study of the Clinical Efficacy and Safety of Different Doses of Valsartan in the Treatment of Chronic Glomerulonephritis Patients with Hypertension

作　　者：魏锦曦 刘镇江[1] 张超[1] 李芹[1] 

机构地区：[1]四川省郫县人民医院肾脏内科,四川成都611730

出　　处：《医学临床研究》2016年第12期2351-2353,共3页Journal of Clinical Research

摘　　要：【目的】探讨缬沙坦治疗慢性肾小球肾炎（CG）并高血压患者的合适剂量与疗效。【方法】选取本院肾脏内科收治的96例CG并高血压患者，采取随机数字表法分为高剂量组（320mg／d缬沙坦口服）和常规剂量组（160mg／d缬沙坦口服），每组各48例，连续用药6个月后评价比较两组患者的临床效果及不良反应。【结果】治疗前两组患者的24h尿蛋白、血肌酐（SCr）、肾小球滤过率（GFR）、血清K＋、尿α1-微球蛋白（α1-MG）、尿N-乙酰-8氨基葡萄糖苷酶（NAG）、半胱氨酸（CysC）的水平两组间比较差异均无显著性（P〈0．05）；治疗后，高剂量组患者的24h尿蛋白、SCr、α1—MG、NAG、CysC的水平显著的低于常规剂量组（P〈0．05），GFR水平显著高于常规剂量组（P〈0．05）；高剂量组患者的不良反应发生率为14．58％（7／48）高于常规组的4．17％（2／48），但两组相比较差异无显著性（P〉0．05）。【结论】高剂量缬沙坦治疗CG并高血压患者有利于延缓患者肾功能恶化的进程，值得临床推广。[Objective]To study the dose and effect of Valsartan in the treatment of chronic glomerulonephritis （CG） patients with hypertension. [Methods] A total of 96 CG patients complicated with hypertension were selected in the Department of Nephrology in our hospital treated. They were divided according to the random table method into a high-dose group （320 mg/d Valsartan oral） and a conventional-dose group （160mg / d Valsartan oral）, with 48 cases in each group. Clinical effects were collected and evaluated after six months of continuous medication. [Results]Before treatment, the levels of 24h urine protein, SCr, GFR, serum K＋ , α1-MG, NAG, and CysC were not statistically significant difference between the two groups level group （ P 〈0.05）. After 6-month treatment, the high dose group patients showed lower levels of 24h urine protein, SCr, α1-MG, NAG and CysC anda higher level of GFR compared to the conventional dose group; the differences were statistical significance （ P 〈0.05）. The incidence of adverse reactions was 14.58% in the high-dose group and 4.17% in the conventional dose group, but the difference was not statistically significant （ P 〉 0.05）. [Conclusion]High doses of Valsartan treatment in chronic glomerulonephritis patients with hypertension is conducive to delaying the process of deterioration of renal function. It has certain clinical and practical value.

关 键 词：肾小球肾炎/并发症 慢性病 高血压/并发症 四唑类/投药和剂量 缬氨酸/类似物和衍生物 

分 类 号：R692.31[医药卫生—泌尿科学]