伊布利特转复房颤中对跨壁复极异质性及室性心律失常的影响分析  

Effects of Ibutilide on Atrial Fibrillation and Transmural Repolarization and Ventricular Arrhythmias

作　　者：陈青远 王新宇 李征 常尚 张勇 唐小霞 

机构地区：[1]徐州肿瘤医院(徐州第三人民医院)心内科,江苏徐州221005

出　　处：《世界复合医学》2016年第4期45-47,共3页World Journal of Complex Medicine

摘　　要：目的分析并探讨伊布利特在转复房颤的过程中对患者跨壁复极异质性及室性心律失常的影响。方法选取该院2013年2月—2015年5月期间收治的发病在48 h^7 d之间的58例房颤患者,将其分为胺碘酮组与伊布利特组,其中胺碘酮组患者共18例,伊布利特组患者共40例,将两组患者的房颤转复成功率进行对比;对比分析两组患者用药之前以及用药后的4 h内QT间期与Tpeak-end/QT间期比值的变化。结果胺碘酮组患者房颤转复的成功率为38.9%,伊布利特组患者的房颤转复的成功率为62.5%,两组患者的房颤转复成功率对比差异有统计学意义(P<0.05);伊布利特组患者用药前QT间期比值为(377±126)ms,用药后0.5 h比值为(468±97)ms,伊布利特组患者用药之后与用药之前相比,QT间期有了显著的延长,Tpeak-end/QT间期比值也有所增大(P<0.05),用药1、2 h后患者的QT间期(428±144)、(392±186)ms与Tpeak-end/QT间期(0.19±0.11)、(0.18±0.06)均又恢复到用药前的水平,差异无统计学意义(P>0.05);胺碘酮组患者用药后的QT间期比用药前有了显著的延长,差异有统计学意义(P<0.01),用药后4 h内Tpeak-end/QT间期比值(0.18±0.09)与用药前(0.19±0.10)相比均无显著性的变化,差异无统计学意义(P>0.05)。结论与胺碘酮相比而言,伊布利特对于房颤患者的转复成功率较高,然而伊布利特患者在用药之后跨壁复极异质性有了一定的增加,增加了室性心律失常的风险,但在1 h内可以恢复正常。Objective To investigate the effect of ibutilide on the heterogeneity of ventricular repolarization and ventricular arrhythmias during the course of AF.Methods Fifty-eight patients with atrial fibrillation from February 2013 to May 2015 were divided into two groups：the amiodarone group and the ibutilide group,and the amiodarone group Patients with a total of 18 cases,a total of 40 patients with Ibutilide group,the two groups of patients with AF success rate of contrast;the two groups of patients before and after medication 4 hours QT interval and Tpeak-end/QT interval.Results Converting atrial fibrillation in patients with amiodarone group success rate of 38.9%,the bullitt group of patients with atrial fibrillation converting the success rate of 62.5%,two groups of patients with atrial fibrillation converting success rate compared with significant difference（P 〈 0.05）;Zlatan ibrahimovic,ratio between QT period before the group of patients medication for（377±126）ms,after 0.5 h ratio for（468±97）ms,Iraq bullitt group later than it was before the medication for treating patients,QT interphase had significantly extended,Tpeak-the period between the end/QT ratio also increased（P 〈 0.05）,after 1 h,2 h between QT period（428±144） in patients with ms,（392±186） between ms and Tpeak-end/QT period（0.19±0.11）,（0.18±0.06）and restored to the level before medication,the difference was statistically significant（P 〉 0.05）;Amiodarone group of patients after QT interphase than the extension of drug use before there has been a significant,the difference wasno statistically significant（P 〈 0.01）,within 4 h after drug Tpeak-the period between the end/QT ratio（0.18±0.09） compared with medication（0.19 ±0.10）before had no significant change,the difference was no statistically significant（P 〉 0.05）.Conclusion Ibutilide hasa higher success rate of conversion in patients with atrial fibrillation compared with amiodarone.However,the heterogeneity of transmural repolarizati

关 键 词：伊布利特 心房颤动 跨壁复极异质性 室性心律失常 

分 类 号：R541[医药卫生—心血管疾病]