慢性阻塞性肺疾病患者血清HSP27和HSP70与肺功能及生活质量的相关性  

Association between the levels of heat shock protein 27 and 70 and pulmonary function and life quality in the patients with chronic obstructive pulmonary disease

作　　者：刘云龙[1] 罗勇[1] 邓桂胜[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院呼吸内科,上海202150

出　　处：《海军医学杂志》2016年第6期505-508,共4页Journal of Navy Medicine

基　　金：崇明区青年科技启明星项目(CQYL2014-12)

摘　　要：目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清HSP27和HSP70水平与肺功能及生活质量的关系。方法选取2015年2月至2016年4月COPD急性加重患者45例(观察组),健康者50例(对照组),采集2组患者血清,采用酶联免疫吸附试验(ELISA)检测血清HSP27和HSP70水平,采用COPD评估测试量表(CAT量表)评估COPD患者的生活质量,并对血清HSP27和HSP70水平与COPD患者肺功能及生活质量的相关性分析。结果与对照组比较,观察组患者血清HSP27和HSP70表达明显升高[(3 590.25±503.42)ng/L vs(1 974.08±527.38)ng/L]和[(331.82±18.61)ng/L vs(162.73±51.52)ng/L],差异有统计学意义(P<0.01)。采用Spearman秩相关分析发现,血清HSP27、HSP70与FEV1呈负相关(r=-0.674、-0.569,P<0.05);观察组CAT量表评分与FEV1呈负相关(r=-0.43,P<0.05);血清HSP27、HSP70水平和CAT量表评分呈正相关(r=0.622、0.53,P<0.05)。结论 CAT量表能有效的评价COPD患者生活质量。HSP27和HSP70参与了COPD的炎症和氧化应激反应,在COPD急性加重患者中具有一定的诊断价值和临床意义。Objective To explore the association between the levels of heat shock protein 27 （ HSP27） and 70 （ HSP70） and pulmonary function and life quality in the patients with chronic obstructive pulmonary disease （ COPD）. Methods Forty-five patients with acute exacerbation of COPD admitted for treatment in our hospital from February 2015 to April 2016 were enrolled for the study, and were divided into the observation group （ n = 45 ） and the control group （50 healthy subjects） . Serum samples were collected from the patients of the 2 groups. The levels of serum HSP27 and HSP70 were detected by ELISA. The life quality of the COPD patients was evaluated by using the CAT scale, and the association between the levels of HSP27 and HSP70 and pulmonary function and life quality was discussed in the paper. Results As compared with those of the control group, the expression levels of HSP27 and HSP70 in the pa-tients of the observation group were significantly increased [（ 3 590. 25 ± 503. 42 ） ng/L vs （ 1 974. 08 ± 527. 38 ） ng/L ] versus [（331.82±18.61） ng/L vs（ 162. 73 ± 51.52） ng/L] （P 〈 0. 01） . Statistical significance was shown when comparisons were made be-tween them（ P 〈 0. 01 ）. Spearman sequence analysis indicated that serum levels of HSP27 and HSP70 were negatively correlated with FEV 1% （r = - 0. 674, - 0. 569, P 〈 0. 05 ） . CAT scores of the observation group were negatively correlated with FEV 1% （r = -0.43, P 〈0. 05） , and the serum levels of HSP27 and HSP70 in the observation group were positively correlated with CAT scores （r = 0. 622,0. 53 , P 〈 0. 05 ） . Conclusion The CAT scale could effectively evaluate the life quality of COPD patients. HSP27 and HSP70 were involved in the process of inflammatory reaction and oxidative stress of COPD, which was of diagnostic value and clinical significance in the treatment of patients with acute exacerbation of COPD.

关 键 词：慢性阻塞性肺疾病 热休克蛋白27 热休克蛋白70 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]