破血消癥中药抗肿瘤转移研究进展  

Research progress in inhibition of Chinese materia medica with breaking blood stasis and resolving mass on tumor metastasis

作　　者：倪雯婷[1,2] 潘燕红[1,2] 王爱云[1,2] 陆茵[1,2] 陈文星[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210023

出　　处：《中草药》2016年第24期4472-4477,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81673648);江苏省高校优势学科建设项目(PAPD);江苏省青蓝工程项目

摘　　要：活血化瘀治则是中医临床抗肿瘤的重要法则之一,活血化瘀中药的抗肿瘤作用也得到大量的研究证实。但近几年实验研究发现某些活血化瘀中药有促进肿瘤转移的作用,从而使活血化瘀中药临床抗肿瘤应用出现争议。破血消癥中药属于活血化瘀药的一种,其效力峻猛,现代研究证实其抗肿瘤作用明显,且进一步的研究发现破血消癥类中药及其有效成分对肿瘤转移具有明显的抑制作用。就破血消癥类中药莪术、三棱、斑蝥、水蛭及其有效成分的抗肿瘤转移作用及其机制研究进行综述,分析认为破血消癥药是一类具有典型抗肿瘤转移作用的活血化瘀药,具有显著的临床应用及开发价值,并认为其抗肿瘤转移实质与影响肿瘤有氧糖酵解的能量代谢密切相关,阐明这一机制可为破血消癥药的临床抗肿瘤及肿瘤转移的应用提供理论指导。Activating blood and dissolving stasis is one of the important principles of clinical anti-tumor by traditional Chinese medicine and the anti-tumor effect of the blood-activating and stasis-resolving drugs has been confirmed by a large number of studies. But in recent years, some experimental studies have found that some blood-activating and stasis-resolving drugs could promote tumor metastasis. And then the clinical application of this kind of drugs has suffered from many controversial problems. Chinese materia medica（CMM） with breaking blood stasis and resolving mass（Poxue herbs） is a kind of blood-activating and stasis-resolving drugs which display the severe effect. Nowadays some researchers confirmed its obvious antineoplastic effect and its prominent anti-tumor metastasis effect, which indicated in recent studies. In this article, we summarized the anti-tumor metastasis effect and mechanism of the Poxue herbs like Curcumae Rhizoma, Sparganii Rhizoma, large blister Beetle, leech, and its effective components in detail. And we also put forward that Poxue herbs are the ones which have the anti-tumor metastasis effect among blood-activating and stasis-resolving drugs, and it valued with significant clinical application and development. It is also believed that the Poxue herbs could inhibit the tumor metastasis which is related with aerobic glycolysis and can provide the theoretical direction to guide clinical application.

关 键 词：破血消癥中药 抗肿瘤转移 有氧糖酵解 能量代谢 活血化瘀 莪术 三棱 斑蝥 水蛭 

分 类 号：R285[医药卫生—中药学]