蒸馏沉淀法制备扑热息痛亲水核-壳分子印迹微球及其吸附性能研究  

Preparation of Molecular Imprinted Polymers with Hydrophilic Shells by Distillation-Precipitation Polymerization and Study on Their Adsorption

作　　者：鲁佩佩 王兵[1] 郭聪[1] 于鹏飞[1] 

机构地区：[1]天津工业大学省部共建分离膜与膜过程国家重点实验室,环境与化学工程学院,天津300387

出　　处：《分析化学》2017年第1期89-96,共8页Chinese Journal of Analytical Chemistry

基　　金：天津市自然科学基金(No.13JCQNJC02600,15JCQNJC13900)资助

摘　　要：选取扑热息痛(PR)作为模板分子,甲基丙烯酸(MAA)为功能单体,通过蒸馏沉淀聚合制得聚合物内核;以丙烯酰胺(AM)作为亲水单体,采用不同的壳交联剂,乙二醇二甲基丙烯酸酯(EGDMA)、3-羟甲基丙烷三甲基丙烯酸酯(TRIM)、N,N'-亚甲基双丙烯酰胺(MBA)通过自由基聚合枝接亲水层外壳,成功制得一系列亲水核-壳分子印迹聚合物微球(CS-MIPs),并对比其对聚合物性能的影响。通过紫外光谱(UV)、红外(FT-IR)光谱、扫描电镜(SEM)以及吸附实验进行表征,并进行了亲水性能测试。结果表明,采用MBA作交联剂的印迹微球吸附性能以及亲水性能最好,吸附量达120μmol/g,接触角23.3°。本研究为检测水溶液中扑热息痛含量,提供了一种新思路。Molecular imprinted polymer cores（MIPs） were prepared through distillation-precipitation polymerization with methacrylic acid（MAA） as the functional monomer and paracetamol（PR） as the template molecule.Then,the hydrophilic shells were grafted successfully by free radical polymerization with acrylamide（AM） as the hydrophilic monomer.The influences of different shell cross-linking agents such as ethylene glycol dimethacrylate（EGDMA）,trimethylolpropane triacrylate（TRIM）,and N,N＇-Methylenebisacrylamide（MBA） on the hydrophilic property were investigated.The resulting MIPs were characterized by various tests,including ultraviolet spectrometry（UV）,Fourier transform infrared spectroscopy（FT-IR）,and scanning electron microscope（SEM）.The absorbing test and contact angle measurement were also carried out for the investigation of hydrophilic property of microspheres.The results showed that MBA was the best shell cross-linking agent of the microspheres,and the adsorption capacity and contact angle of this prepared microsphere could reach 120 μmol/g and 23.3°,respectively.Core-shell（CS）-MIPs provide a new thought for detection of PR in aqueous solution.

关 键 词：亲水性 核壳 蒸馏沉淀聚合 自由基聚合 分子印迹 扑热息痛 

分 类 号：R927[医药卫生—药学] O631.3[理学—高分子化学]