1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察  

A multicenter study on curative effect of 1% luliconazole cream in treatment of candidal balanoposthitis

作　　者：高方铭 易江华[2] 叶兴东[1] 肖常青[1] 高爱莉[1] 刘玉梅[1] 戴向农[1] 

机构地区：[1]广州医科大学皮肤病研究所广州市皮肤病防治所,广州510095 [2]广州医科大学附属第三医院皮肤科,广州510145

出　　处：《中国真菌学杂志》2016年第6期381-384,共4页Chinese Journal of Mycology

基　　金：中国中西医结合临床研究基金(CAIM-LLKZ-002)

摘　　要：目的观察1%卢立康唑乳膏治疗念珠菌性包皮龟头炎临床疗效及安全性。方法 70例患者随机分为两组,治疗组38例,对照组32例,分别外涂1%卢立康唑乳膏与2%酮康唑乳膏,每日1次,治疗1周及2周后根据临床症状、体征及真菌学检查判定疗效,并根据不良反应评价其安全性。结果卢立康唑乳膏组1周真菌学清除率高于酮康唑乳膏组,差异有统计学意义(P<0.05),而临床疗效及2周真菌学清除率,两组差异无统计学意义(P>0.05);两组在临床疗效、症状及体征评分方面未见明显差异(P>0.05)。结论 1%卢立康唑乳膏治疗念珠菌性包皮龟头炎具有良好的疗效及安全性,值得临床推广。Objective To investigate the curative efficiency and safety of luliconazole 1 ~ cream in treating candidal balano- posthitis.Methods A total of 70 outpatients from department of Dermatology ＆ STD were randomly divided into two groups.Among them, 38 were given luliconazole 1% cream once a day （study group） while the others were given ketoconazole cream once a day （control group）,The effect was evaluated based on scores of relief for symptoms,skin signs,and mycology inspection, while the safety was evaluated according to the side effects.Results The mycological clearance rate of 1% lulicon azole cream was significantly higher than that of 2% ketoconazole cream one week after treatment （P〈0.05）,but there was no significant difference of clinical efficacy and mycological clearance rate between the two groups two weeks after treatment （P 〉0,05）.No significant difference was observed between the two groups in evaluation scores of clinical effect, symptom and skin sign aspects.Conclusions The curative effect and safety for 1%luliconazole cream were comparable to those of 2% ketoconazole cream in treating candidal balanoposthitis.It is worth popularizing and applying clinically.

关 键 词：卢立康唑 念珠菌性包皮龟头炎 疗效观察 

分 类 号：R519.3[医药卫生—内科学]