地佐辛超前镇痛用于小儿腹腔镜疝修补术的研究  

Application of Dezocine Preemptive Analgesia in Children Undergoing Laparoscope Hernia Repaired Operation

作　　者：吴涛[1] 陈嘉萍[1] WU Tao CHEN Jia-ping.(The Seeond Affiliated Hospital of Shantou University Medical College , Shantou515041, China)

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《中外医学研究》2017年第1期8-10,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：二O一五年度汕头市医疗科技计划项目(项目编号:20150406)

摘　　要：目的:研究地佐辛超前镇痛在小儿腹腔镜疝修补术的效果。方法:选择在静脉复合全麻下行腹腔镜疝修补术的60例患儿,采用随机数字表法分成3组:地佐辛超前镇痛组(A、B组),对照组(C组),每组20例。A组于手术开始前15 min缓慢静脉注射地佐辛0.1 mg/kg,B组手术开始前15 min缓慢静脉注射地佐辛0.2 mg/kg,C组手术开始前15 min缓慢静脉注射生理盐水2 ml。观察呼吸恢复、苏醒及拔管时间;术后0、4、8 h的视觉模拟评分法(VAS)、改良目的评分法(MOPS)和镇静躁动评分(SAS);各时间点的生命体征及不良反应。结果:A组、B组镇痛VAS评分和MOPS评分在术后各时间段明显低于C组,镇静SAS评分低于C组,差异均有统计学意义(P<0.05;苏醒及拔管时间比较差异无统计学意义(P>0.05)。结论:0.2 mg/kg地佐辛超前镇痛用于小儿腹腔镜疝修补术,镇痛效果较好,明显减少躁动的发生,不影响复苏时间,无明显不良反应。Objective： To investigate the efficacy of Dezocine preemptive analgesia in children undergoing laparoscope hernia repaired operation. Method ： 60 cases of children undergoing laparoscope hernia repaired operation were randomly divided into three groups.The patients in group A were treated with Dezocine injection at 0.1 mg/kg dosage after anesthesia before operation 15 min.The patients in group B were treated with Dezocine injection at 0.2 mg/kg dosage after anesthesia before operation 15 min.The patients in group C were treated with 2 ml normal saline as control after anesthesia before operation 15 min.Pain scores, respiratory recovery, vital signs and adverse reactions, time of consciousness resume and pulling out tracheal tube were oberserved.Pain score was assessed by Visual analogue scalc（VAS）, modified objective scoring method（MOPS） and sedation agitation score（SAS） at 0, 4, 8 h after operation.Result： Pain VAS and MOPS of group A and B was significantly reduced compared to group C, the difference was statistically significant（P〈0.05） at all time points.SAS were significantly reduced compared to group C, the difference was statistically significant（P〈0.05） .There were no difference in the the time of consciousness resume and pulling out tracheal tube among three groups（P〉0.05 ）.Conclusion： Preemptive Dezocine injection at 0.2 mg/kg can more effectively reduce postoperative acute pain and delirium during analepsia without apparent side effect, indicate its safety in postoperative analgesia in children.

关 键 词：地佐辛 超前镇痛 小儿 腹腔镜 躁动 

分 类 号：R726.1[医药卫生—儿科]