基于复杂网络分析回顾性研究艾滋病中医方药规律  

Analysis on Prescription Rule of Chinese Medicine for AIDS by Retrospective Study Based on Complex Network Analysis

作　　者：王丹妮[1] 蒋自强[1] 许前磊[1] 金艳涛[1] 吴涛[1] 陈莉华[1] 李鹏宇[1] 李政伟[1] 郭会军[1] 

机构地区：[1]河南中医学院第一附属医院,郑州450000

出　　处：《中国实验方剂学杂志》2017年第3期187-191,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81102575);国家中医药管理局基地专项(JDZX2015164);河南省中医药科学研究专项(2014ZY02035);河南中医学院中医药与经济社会发展研究中心科研项目(2015JDYB15);河南中医学院科技创新人才项目(2016XCXR03)

摘　　要：目的:挖掘中医药治疗艾滋病方药配伍规律,为中医药治疗艾滋病的方药提供客观参考依据。方法:利用复杂网络分析方法,回顾性研究2010年1月—2011年4月在河南、安徽、湖北采集的2 674个中草药处方,分析中医药治疗艾滋病核心药物、配伍规律和常用方药特点。结果:运用多维检索查询分析得出,本次研究中治疗艾滋病的核心药物主要为白术、炙甘草、人参、大枣、甘草、黄芪、山药、党参、白扁豆等补气药物,当归、白芍、熟地黄等补血药物,茯苓、薏苡仁、砂仁、泽泻等祛湿药物;核心处方为补中益气汤、香砂六君汤、参苓白术散等加减。结论:艾滋病病机以气血两虚兼有湿立论的正确性,治疗应益气健脾祛湿。此次应用复杂网络分析法对科研病历回顾性研究探讨治疗艾滋病的中医方药规律得出结论与临床基本一致。Objective： To explore the prescription rules of traditional Chinese medicine in treatment of AIDS and provide objective basis for Chinese medicine treatment of AIDS. Method： Complex network analysis method was used to retrospectively study 2 674 Chinese herbal prescriptions collected from January 2010 to April2010 in Henan,Anhui,and Hubei. Then the core herbs,compatibility rules and characteristics of commonly used prescriptions for AIDS were analyzed. Result： Multidimensional retrieving results showed that the core TCM herbs for AIDS mainly included Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle,Ginseng Radix et Rhizoma,Jujubae Fructus,Glycyrrhizae Radix et Rhizoma,Astragali Radix,Dioscorea Rhizoma,Codonopsis Radix,Lablab semen Album and other Qi tonifying herbs; Angelicae Sinensis Radix,Paeoniae Radix Alba,Rehmanniae Radix Praeparata and other blood tonifying herbs; Poria,Coicis Semen,Amomi Fructus,Alismatis Rhizoma and other dampness clearing herbs. Core prescriptions included Buzhong Yiqi Tang,Xiangsha Liujuntang,and Shenling Baizhu San. Conclusion： The pathogenesis of HIV/AIDS was shown as Qiblood deficiency and dampness,so the treatment should be replenishing Qi,invigorating spleen and clearing dampness. The results in complex network analysis method in the scientific research and medical records of this paper were basically consistent with the clinical application.

关 键 词：艾滋病 核心药物 用药规律 复杂网络分析 

分 类 号：R287[医药卫生—中药学]