HMGB1在急性肠套叠患儿血清中的表达及其临床意义  

Expression of HMGB1 in infants with intussusception and clinical significance

作　　者：段永福[1] 熊顺军[2] 

机构地区：[1]河南省南阳市中心医院小儿外科,河南南阳473000 [2]武汉大学中南医院儿科,湖北武汉430071

出　　处：《中国现代医学杂志》2017年第1期46-49,共4页China Journal of Modern Medicine

基　　金：湖北省卫生厅课题(No:JX3B24)

摘　　要：目的探讨高迁移率族蛋白1(HMGB1)在小儿急性肠套叠外周血中的表达及其临床意义。方法选取2010年10月-2015年6月在该院接受治疗的急性肠套叠患儿89例,取同期体检的89例健康婴幼儿作为对照组,采用酶联免疫吸附法检测受检对象外周静脉血中HMGB1的表达,同时检测两组研究对象外周血中肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)的表达水平。结果与对照组比较,急性肠套叠患儿外周血中肿瘤坏死因子(TNF-α)、白介素6(IL-6)及HMGB1水平升高(P<0.05),进一步研究发现,HMGB1的表达量与TNF-α、IL-6的表达水平相关;受试者工作特征曲线表明,以12.35 ng/ml为临界值,HMGB1用于诊断急性肠套叠的敏感性为70.79%,特异性为79.78%。结论小儿急性肠套叠外周血中HMGB1的表达量升高,早期检测其表达可能对急性肠套叠的诊断具有一定意义。Objective To evaluate the expression and clinical significance of serum high mobility group box-1 protein （HMGB1） in infants with intussusception. Methods Eighty-nine infants with intussusception admitted to our department between October 2010 and June 2015 were enrolled in this prospective study, and 89 health children having physical examination during the same period were selected into control group. Interleukin-6 （IL-6）, tumor necrosis factor α（TNF-α） and HMGBI were estimated at the time of admission. Results Children with intussusception had higher levels of HMGB1, IL-6 and TNF-α when compared with the control group （P〈 0.05）. HMGB1 was in positive correlations with IL-6 and TNF-α （P〈 0.05） in children with intussusception. Using the ROC curve, the boundary value of HMGB1 was 12.35 ng/ml. The sensitivity and specificity of HMGB1 for the diagnosis of intussusception were 70.79% and 79.78%, respectively. Conclusions Serum level of HMGB1 increases in the infants with intussusception. Early detection of serum HMGB1 may have certain significance for the diagnosis of intussusception in infants.

关 键 词：急性肠套叠 小儿 高迁移率族蛋白1 

分 类 号：R91[医药卫生—药学]