癌症精准医疗的瞄准镜和雷达之“液体活检”——微流控器件—核酸质谱集成装备研制及在肿瘤精准医学中的应用解决方案  

Liquid biopsy:the gunsight and radar of precision medicine-fabrication of microchip-nucleic acids mass spectra equipment and its application in precision medicine

作　　者：董海峰[1] 赵亮[1] 张学记[1] Dong Haifeng Zhao Liang Zhang Xueji(University of Science and Technology Beijing , Beijing China, 100083,China)

机构地区：[1]北京科技大学,北京100083

出　　处：《分析仪器》2017年第1期45-47,共3页Analytical Instrumentation

摘　　要：液体活检通过分析外周血中循环肿瘤细胞(CTC)和循环肿瘤核酸(ctDNA、microRNA)基因的表达和变异,从而获取肿瘤发生、转移和治疗的信息,在肿瘤的精准治疗中具有广阔的应用前景。发展有效的CTC、ctDNA及microRNA的检测仪器显得尤为重要。本文分析了目前国内外液体活检的相关仪器;介绍了"数字诊疗装备研发"国家重点专项"微流控器件-核酸质谱集成装备研制及在肿瘤精准医学中的应用解决方案"的研发情况。Liquid biopsy, that is, analysis of gene mutations and expression related to tumorigenesis, metastasis and therapy on circulating tumor cells （CTC） and cell-free circulating tumor DNA （ctDNA） or microRNA released into the peripheral blood from metastatic deposits, hold a great promise in precision medicine. Developing efficient detection equipment is significant. We analyze the recent processes in the ＂liquid biopsy＂ instrument. Specially, we discuss the project of ＂Fabrication of Microchip-Nucleic Acids Mass Spectra Equipment and its Application in Precision Medicine＂, which is one of the state key project of ＂Research of Digital Theranostic Equipment ＂

关 键 词：循环肿瘤细胞 循环肿瘤核酸 液体活检 微流控 核酸质谱 

分 类 号：R197.39[医药卫生—卫生事业管理]