25-（OH）D3与相关血液微量元素的相关性研究  

Study on the relativity between the microelements, BAKP and 25-（OH）D3

作　　者：谭丹凤[1] 

机构地区：[1]湖南省妇幼保健院儿童保健科,长沙410007

出　　处：《国际医药卫生导报》2017年第2期172-174,共3页International Medicine and Health Guidance News

摘　　要：目的测定不同年龄段儿童的血清25-（OH）D3（25-羟维生素D3）的含量，并探究25-（OH）D3与BAKP（骨碱性磷酸酶）及微量元素的相关性。方法随机选择382例本院儿童保健所门诊正常体检儿童作为研究对象，根据年龄分为0～1岁、1，2岁、2～3岁、3～4岁、4-5岁共5组，采用酶联免疫测试法检测血清25-（OH）D3含量，并测定血清BAKP及cu、Zn、Fe、Mg等微量元素含量，分析25-（OH）D3与BAKP、微量元素的相关性。结果各年龄段儿童均明显存在25-（OH）D3缺乏的现象。采用Pearson相关性检验表明，zn和BAKP、Cu，Fe和BAKP、Cu、Zn，Mg和Cu、Z、Fe之间均存在明显的相关性（P〈0．05）；25-（OH）D3与BAKP存在相关性（P〈0．05）；而25-（OH）D3与Cu、Zn、Fe、Mg等微量元素之间均无明显相关性（P〉0．05）。结论0-5岁的儿童均不同程度地缺乏25-（OH）D3，尤其是0～2岁的儿童缺乏25-（OH）D3现象严重。相关性分析说明25-（OH）D3与BAKP存在相关性，与Cu、Zn、Fe、Mg等微量元素无相关性，补充Zn和Fe可有助于改善BAKP含量，对改善儿童身体健康具有重要意义。Objective To measure the level of serum 25-hydroxy vitamin D3 [25-（OH）D3] of children of different ages, arid investigate the relativity between the microelements, bone alkaline phosphatase （BAKP） and 25-（OH）D3. Methods 382 children who underwent routine physical examination in the health care center of our hospital were randomly selected as the research object, and divided into 5 groups according to their different ages, namely 0-1, 1-2, 2-3, 3-4, 4-5 years old. Measured the level of serum 25-（OH）D3 with ELISA, measured the levels of serum BAKP, the microelements （Cu, Zn, Fe, Mg）, analyzed the relativity between the microelements, BAKP and 25-（OH）D3. Results Children of all ages were obvious lack of 25-（OH）D3. Pearson correlation examine analysis results showed that there were obvious relativity between Zn and BAKP, Cu; Fe and BAKP, Cu, Zn; Mg and Cu, Z, Fe （P〈0.05）. There was relativity between 25-（OH）D3 and BAKP （P〈0.05）. There were no obvious relativity between 25-（OH）D3 and Cu, Zn, Fe, Mg （P〉0.05）. Conclusioas Children of 0-5 years old have different degree of lack of 25-（OH）D3, children of 0-2 years old are obvious lack of 25-（OH）D3. The relativity analysis shows that there is relativity between 25-（OH）D3 and BAKP, there were no relativity between 25-（OH）D3 and Cu, Zn, Fe, Mg. Adding Zn and Fe can improve the BAKP content, which is very beneficial for children＇s health.

关 键 词：25-(OH)D3 BAKP 微量元素 

分 类 号：R723.2[医药卫生—儿科]