老年哮喘患者呼出气一氧化氮水平与病情严重程度和治疗效果的关系  

Level of fractional exhaled nitricoxide in patient with elderly asthma and its relationship with bronchial asthma severity treatment effect

作　　者：陈存国[1] 金华良[2] CHEN Cun-guo JIN Hua-liang(Department of Geriatrics Taizhou Hospital, Taizhou , Zhejiang 317000, China)

机构地区：[1]浙江省台州医院老年医学科,浙江台州317000 [2]杭州市第一人民医院呼吸内科,浙江杭州310006

出　　处：《中华全科医学》2017年第1期33-35,共3页Chinese Journal of General Practice

基　　金：浙江省2014年医药卫生一般项目(2014KYA170)

摘　　要：目的观察老年哮喘患者呼出气一氧化氮水平(fractional exhaled nitricoxide,Fe NO)及其与病情严重程度和治疗效果的关系。方法选择2014年1月—2016年6月浙江省台州医院老年哮喘患者90例作为观察组,健康体检者45例作为对照组,观察组被分为急性发作组和缓解组;根据FEV1%分为1级、2级和3级,缓解组根据是否应用激素治疗分为激素治疗组和无激素治疗组。测定2组患者Fe NO水平。结果急性发作期组FEV1%低于缓解期组和对照组(P<0.05);急性发作期组Fe NO高于缓解期组和对照组(P<0.05),缓解期组高于对照组(P<0.05)。无激素治疗组Fe NO高于激素治疗组和对照组(P<0.05),激素治疗组高于对照组(P<0.05)。1级组Fe NO高于2级组和3级组(P<0.05),2级组和3级组比较差异无统计学意义(P>0.05)。老年哮喘急性发作期患者Fe NO和FEV1%呈负相关(r=-0.441,P=0.008);老年哮喘缓解期组患者Fe NO和FEV1%无显著相关性(r=0.151,P=0.425)。结论老年哮喘急性发作患者Fe NO水平升高,FEV1%下降,两者呈负相关,FeNO水平与病情严重程度和治疗效果有关。Objective To observe the fractional exhaled nitricoxide （FeNO） level of elderly asthma and its relationship with bronchial asthma severity treatment effect. Methods Ninety cases of elderly patients with bronchial asthma were selected as observation group and 45 cases of healthy as control group from January,2014 to June ,2016 in Taizhou hospital. The observation group patients were divided into acute exacerbation group and remission group ; and were divided into level 1 ,level 2 and level 3 according to FEVI%. The remission group patients were divided into hormone therapy group and non-hormone therapy group according to whether hormone therapy. FeNO levels in both groups were measured. Re- suits The FEV1% of acute exacerbation group was lower than that of remission group and control group （ P 〈 0.05 ） ; the FeNO of acute exacerbation group was higher than that of remission group and control group（P 〈 0. 05）, the FeNO of re- mission group was higher than that of control group（ P 〈 O. 05 ）. The FeNO of non-hormone therapy group was higher than that of hormone therapy group and control group（P 〈0.05） ,the FeNO of hormone therapy group was higher than that of control group （P 〈 0.05 ）. The FeNO of level 1 group was higher than that of level 2 group and level 3 group （P 〈 0.05 ）, the difference of FeNO between level 2 group and level 3 group was no statistical significance（P 〉 0.05 ）. The FeNO was negative correlation with FEV1% in acute exacerbation elderly asthma patients（ r = -0. 441 ,P = 0. 008） ;the FeNO was no correlation with FEV1% in remission elderly asthma patients （r = 0.151, P = 0. 425 ）. Conclusion In patients with a- cute elderly asthma attack, FeNO levels elevates, FEVI% declines, FeNO was negative correlation with FEVI%. FeNO level is related to severity of the disease and treatment effect.

关 键 词：老年哮喘 呼出气一氧化氮 1秒钟用力呼气容积占预计值百分比 

分 类 号：R562.25[医药卫生—呼吸系统]