电针对雌雄两性实验肥胖大鼠血清Ins及脂肪含量的影响  

Effect of Electroacupuncture on Serum Ins and the Fat Content in Male and Female Experimental Obesity Rats

作　　者：田玲[1] 张书义 高飞[3] 孙小雪[3] 杜潇怡 孙立虹[1] 梁玉磊[1] 

机构地区：[1]河北中医学院,石家庄050200 [2]北京市丰台社区卫生服务中心,北京100071 [3]河北医科大学,石家庄050017

出　　处：《上海针灸杂志》2017年第1期94-97,共4页Shanghai Journal of Acupuncture and Moxibustion

基　　金：河北省中医药管理局科学研究计划项目(2010002)

摘　　要：目的探讨电针刺激对雌、雄两性单纯性肥胖大鼠血清胰岛素(Ins)调节及脂肪消耗的差异性及其可能作用机制。方法采用谷氨酸钠的方法制造单纯性肥胖大鼠模型,随机分为模型组(雌、雄)、电针组(雌、雄),并设正常组(雌、雄)进行对照,每组10只。电针组取曲池、中脘、关元、后三里、丰隆、三阴交穴,针刺后采用2Hz低频刺激,每日1次,连续治疗28 d。观察电针治疗前后雌、雄大鼠血清ins含量及大网膜脂肪、心周脂肪、肾周脂肪重量的变化情况,并进行比较。结果电针组雄性与雌性大鼠血清Ins含量及大网膜脂肪、心周脂肪、肾周脂肪的重量分别较模型组同性大鼠显著降低(P<0.01),且电针组雄性大鼠各项指标较电针组雌性大鼠降低更明显(P<0.05)。结论电针刺激对雌、雄两性肥胖性大鼠均有不同程度的减肥作用,在降低血清Ins及大网膜脂肪、心周脂肪、肾周脂肪重量方面,雄性大鼠疗效更显著。Objective To explore the difference in the regulating effect of electroacupuncture on serum insulin （Ins） and fat consumption between male and female simple obesity rat and the possible mechanism of its action. Methods A rat model of simple obesity was made by induction with sodium glutamate. The rats were randomized into model and electroacupuncture groups （male and female）, 10 rats each. A normal group of 10 rats （male and female） was established as a control. Points Quchi, Zhongwan, Guanyuan, Housanli, Fenglong and Sanyinjiao were selected in the electroacupuncture group. Stimulation with a low frequency of 2 Hz was provided after needle insertion. The treatment was given once daily for 28 consecutive days. Serum Ins content, and greater omentum, pericardiac and perirenal fat weights were measured in the male and female groups of rats before and after electroacupuncture intervention. The comparisons were made. Results Serum Ins content, and greater omentum, pericardiac and perirenal fat weights were significantly lower in the electroacupuncture male and female groups of rats than in the model male and female groups of rats （P〈0.01） and also in the electroacupuncture male group of rats than in the electroacupuncture female group of rats （P〈0.05）. Conclusions Electroacupuncture has different degrees of weight-reducing effect in both male and female obesity rats. The reducing effect on serum Ins content, and greater omentum, pericardiac and perirenal fat weights is better in male obesity rats.

关 键 词：电针 肥胖症 大鼠 血清Ins 大网膜脂肪 心周脂肪 肾周脂肪 

分 类 号：R203[医药卫生—中医学]