高迁移率族蛋白B1与p53的相互作用及其临床意义  

Clinical significance and interaction mechanism of high mobility group box - 1 protein and p53

作　　者：贾敏[1] 张卉[2] 童亚林[1] 姚咏明[2] 

机构地区：[1]解放军第一八一医院烧伤整形中心,桂林541002 [2]解放军总医院第一附属医院创伤研究中心,北京100048

出　　处：《中华实验外科杂志》2017年第1期170-173,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81372054、81130035）;国家重点基础研究发展计划项目（2012CB518102）

摘　　要：高迁移率族蛋白B1（HMGB1）是一种普遍存在的核蛋白，它作为晚期炎性因子参与调节免疫及炎性反应。p53作为一种古老的肿瘤基因，也参与调节免疫反应。新近发现，p53与HMGB1存在相互调节作用。细胞核内，HMGB1可促进p53和DNA的结合，影响靶基因的转录效应；细胞质内，HMGB1与p53形成复合体共同调节细胞的凋亡与自噬之间的平衡；胞外的HMGB1可能通过某些分子通路影响p53的功能。本文重点综述了HMGB1与p53的相互作用及其临床意义。High mobility group box - 1 protein （HMGB1） is a ubiquitous nuclear protein, which is also con- cerned as a late inflammatory factor involved in the regulation of immune and inflammatory response. Tumor protein 53 （ p53 ）, an ancient tumor gene, is also involved in the immune reaction. Recent reports indicate an interaction between HMGB1 and p53. In the nucleus, HMGB1 promotes p53 binding to DNA and then affects the transcriptions of target genes. In the cytoplasm, HMGBland p53 construct a complex which regulates the balance between cell apoptosis and autophagy. Extraeellular HMGB1 may affect the function of p53 through some molecular pathways. In this review, we summarize the interaction mechanism and clinical significance of HMGBI and p53.

关 键 词：高迁移率族蛋白B1 P53 脓毒症 

分 类 号：R3411[医药卫生—基础医学]