芬太尼透皮贴剂联合吗啡皮下注射治疗晚期肝癌介入治疗后疼痛的护理观察  

Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy

作　　者：朱恒美[1] 鲁桂华[2] 房树恒 许丽丽[1] 

机构地区：[1]第二军医大学东方肝胆外科医院特需一科,上海200438 [2]第二军医大学长海医院血液科,上海200433

出　　处：《药学实践杂志》2017年第1期75-77,共3页Journal of Pharmaceutical Practice

摘　　要：目的观察芬太尼透皮贴剂联合吗啡皮下注射在晚期肝癌介入术后疼痛护理应用中的优势。方法回顾性分析166例晚期肝癌介入治疗后疼痛治疗护理的临床资料,对89例芬太尼联合吗啡治疗组和77例吗啡治疗组在疼痛评分、缓解率两方面数据进行比较,并进行统计学分析;同时记录各组治疗中的副反应。结果与吗啡治疗组比较,芬太尼联合组疼痛评分,在12h(1.97±0.56 vs 3.23±1.49,P<0.05)以及24h(1.63±0.44 vs 4.19±1.68,P<0.01)均有显著降低。与吗啡治疗组比较,芬太尼联合组介入治疗后疼痛总缓解率,在介入后12h(92.1%vs 76.6%,P<0.05)以及24h(97.8%vs70.1%,P<0.05)均有显著缓解。结论晚期肝癌介入治疗后联合使用吗啡皮下注射+芬太尼透皮贴剂外贴治疗,可以显著提高患者介入术后72h内的疼痛缓解率。Objective To evaluate the effects of fentanyl transdermal combined with morphine subcutaneous injection in the management of advanced liver cancer pain after intervention. Methods 166 patients who suffered from advanced liver cancer and received intervention therapy in our hospital were divided into two groups. 89 patients belong to the fentanyl transdermal combined with morphine subcutaneous injection treatment group. 77 patients belong to the morphine subcutaneous injection treatment group. The pain score and the remission rate of the two groups were compared and analyzed statistically. Meanwhile, the side effects of each group were recorded. Results Pain score in the group with fentanyl transdermal and morphine treatment was significantly lower than morphine mono therapy. 12 hours after intervention therapy, （1.97±0.56 for combination treatment vs 3.23±1.49 for morphine only group, P〈0.05）. 24 hours after intervention therapy, （1.63±0.44 for combination vs 4.19±1.68 for morphine only group, P〈0.01）. Similarly, the remission rate of the fentanyl transdermal combined with morphine subcutaneous injection group improved significantly, （92.1% vs 76.6 % P〈0. 05） 12 hours after intervention therapy, and（97.8% vs 70.1%, P〈0. 05） 24 hours after intervention therapy. Conclusions The addition of fentanyl transdermal to morphine subcutaneous injection treatment significantly improve the pain remission rate for the patients with advanced liver cancer pain 72 hours after intervention therapy.

关 键 词：疼痛治疗 芬太尼透皮贴剂 回顾性分析 疼痛缓解 

分 类 号：R971[医药卫生—药品] R473[医药卫生—药学]