2,3,6-三氯吡啶催化加氢制备2,3-二氯吡啶  

Synthesis of 2,3-Dichloropyridine by Catalytic Hydrogenation of 2,3,6-Trichloropyridine

作　　者：龚亚军[1] 陈二中 刘冰[1] 周晨[1] 尹荃[1] 闫海生[1] 

机构地区：[1]沈阳化工研究院有限公司,沈阳110021

出　　处：《农药》2017年第1期11-13,共3页Agrochemicals

摘　　要：[目的]对缚酸剂进行筛选,并对溶剂甲醇-水体积配比、反应温度、压力及催化剂投量等进行考察。[方法]以2,3,6-三氯吡啶为原料,通过催化加氢的方法制备2,3-二氯吡啶。[结果]得到以甲酸钠为缚酸剂,在反应温度40℃、氢气压力0.4 MPa、催化剂投量0.25%、溶剂甲醇/水体积比3∶2条件下,反应2 h,原料转化率为89.0%,2,3-二氯吡啶最高摩尔收率达到70.5%。[Aims] The acid-binding agent, the volume ratio of methanol-water mixed solvents, temperature, pressure and catalyst dosage were investigated. [Methods] Catalytic hydrogenation of 2,3,6-trichloropyfidine was investigated to synthesis 2,3-dichloropyridine. [Results] The experimental results showed that the reaction was conducted for 2 hours at 40 ℃ under hydrogen pressure of 0.2 MPa with the catalyst dosage 0.25%, the volume ratio of methanol/water 3：2, the 2,3-dichloropyridine yield reached the maximum of 70.5% with the 2,3,6-trichloropyridine conversation of 89.0%.

关 键 词：2 3 6-三氯吡啶 2 3-二氯吡啶 催化加氢 缚酸剂 

分 类 号：O643.3[理学—物理化学] TQ253.2[理学—化学]